Pex14 peroxisomal biogenesis factor 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pex14provided by MGI
Official Full Name: peroxisomal biogenesis factor 14provided by MGI
Primary source: MGI:MGI:1927868
See related: Ensembl:ENSMUSG00000028975 AllianceGenome:MGI:1927868
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pex14p
Summary: Predicted to enable several functions, including identical protein binding activity; protein N-terminus binding activity; and tubulin binding activity. Predicted to be involved in several processes, including peroxisome transport along microtubule; protein import into peroxisome matrix; and regulation of transcription, DNA-templated. Predicted to act upstream of or within protein transport. Located in peroxisomal membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 13A. Orthologous to human PEX14 (peroxisomal biogenesis factor 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 52.9), duodenum adult (RPKM 28.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 78.87 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (149044992..149184300, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (148960535..149099843, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation.
Title: The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC38258 (e-PCR)
- UniSTS:50262

MDB1083 (e-PCR)
- UniSTS:125045

RH125171 (e-PCR)
- UniSTS:161993

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in peroxisome organization	ISO Inferred from Sequence Orthology more info
involved_in peroxisome transport along microtubule	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome matrix	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome matrix, docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into peroxisome matrix, docking	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome matrix, substrate release	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome matrix, translocation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of peroxisomal importomer complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisomal membrane protein PEX14

Names: PTS1 receptor-docking protein; peroxin-14; peroxisomal membrane anchor protein PEX14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.