Tet1 tet methylcytosine dioxygenase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tet1provided by MGI
Official Full Name: tet methylcytosine dioxygenase 1provided by MGI
Primary source: MGI:MGI:1098693
See related: Ensembl:ENSMUSG00000047146 AllianceGenome:MGI:1098693
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LCX; Cxxc6; mKIAA1676; D10Ertd17e; 2510010B09Rik
Summary: Enables methylcytosine dioxygenase activity. Involved in several processes, including dendrite morphogenesis; inner cell mass cell differentiation; and protein O-linked glycosylation. Acts upstream of or within DNA demethylation; regulation of DNA methylation; and regulation of genetic imprinting. Located in nucleus. Is expressed in several structures, including brain; early conceptus; embryo ectoderm; lower urogenital tract; and reproductive system. Orthologous to human TET1 (tet methylcytosine dioxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 2.2), whole brain E14.5 (RPKM 2.0) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 32.48 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (62640349..62723242, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (62804570..62887469, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Iterative oxidation by TET1 is required for reprogramming of imprinting control regions and patterning of mouse sperm hypomethylated regions.
Title: Iterative oxidation by TET1 is required for reprogramming of imprinting control regions and patterning of mouse sperm hypomethylated regions.
ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1.
Title: ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1.
TET1-mediated epigenetic regulation of tumor necrosis factor-alpha in trigeminal ganglia contributes to chronic temporomandibular joint pain.
Title: TET1-mediated epigenetic regulation of tumor necrosis factor-α in trigeminal ganglia contributes to chronic temporomandibular joint pain.
TET1 Regulates Proliferation of Mouse Skin-Derived Stem Cells In Vitro.
Title: TET1 Regulates Proliferation of Mouse Skin-Derived Stem Cells In Vitro.
TET1 Regulates Skeletal Stem-Cell Mediated Cartilage Regeneration.
Title: TET1 Regulates Skeletal Stem-Cell Mediated Cartilage Regeneration.
Specific inhibition of TET1 in the spinal dorsal horn alleviates inflammatory pain in mice by regulating synaptic plasticity.
Title: Specific inhibition of TET1 in the spinal dorsal horn alleviates inflammatory pain in mice by regulating synaptic plasticity.
Tet1 deficiency exacerbates oxidative stress in acute kidney injury by regulating superoxide dismutase.
Title: Tet1 deficiency exacerbates oxidative stress in acute kidney injury by regulating superoxide dismutase.
Role of TET1-mediated epigenetic modulation in Alzheimer's disease.
Title: Role of TET1-mediated epigenetic modulation in Alzheimer's disease.
Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation.
Title: Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation.
TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype.
Title: TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype.

Submit: New GeneRIF Correction See all GeneRIFs (135)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (3)
Spontaneous (1) 1 citation
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124473 (e-PCR)
- UniSTS:161295

RH126562 (e-PCR)
- UniSTS:209688

RH126560 (e-PCR)
- UniSTS:167007

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

D20Got10 (e-PCR)
- UniSTS:113006

AW536066 (e-PCR)
- UniSTS:208547

Tet1 (e-PCR), detects polymorphism
- UniSTS:531424

BB001228 (e-PCR)
- UniSTS:185833

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 5-methylcytosine dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5-methylcytosine dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 5-methylcytosine dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyl-CpG binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 5-methylcytosine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in DNA demethylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA demethylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within DNA demethylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epigenetic programing of male pronucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner cell mass cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner cell mass cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of gene expression via chromosomal CpG island demethylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression via chromosomal CpG island demethylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression via chromosomal CpG island demethylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: methylcytosine dioxygenase TET1

Names: CXXC finger 6; CXXC-type zinc finger protein 6; ten-eleven translocation 1 gene protein homolog; tet oncogene 1

NP_001240786.1

EC 1.14.11.80

NP_001393310.1

EC 1.14.11.80

NP_001393311.1

EC 1.14.11.80

NP_001393312.1

EC 1.14.11.80

XP_006513930.1

EC 1.14.11.80

XP_030101034.1

EC 1.14.11.80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001253857.2 → NP_001240786.1 methylcytosine dioxygenase TET1 isoform 1

See identical proteins and their annotated locations for NP_001240786.1

Status: VALIDATED

Source sequence(s)

AC166359

Consensus CDS

CCDS56706.1

UniProtKB/Swiss-Prot

D0VLQ4, E9Q9Y4, Q3URK3, Q6ZPK2, Q9CY36

UniProtKB/TrEMBL

A0A9L6H7S7

Related

ENSMUSP00000133279.2, ENSMUST00000174189.2

Conserved Domains (2) summary

pfam02008
Location:568 → 607

zf-CXXC; CXXC zinc finger domain

pfam12851
Location:1528 → 1686

Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
NM_001406381.1 → NP_001393310.1 methylcytosine dioxygenase TET1 isoform 3

Status: VALIDATED

Source sequence(s)

AC166359
NM_001406382.1 → NP_001393311.1 methylcytosine dioxygenase TET1 isoform 5

Status: VALIDATED

Source sequence(s)

AC166359
NM_001406383.1 → NP_001393312.1 methylcytosine dioxygenase TET1 isoform 4

Status: VALIDATED

Source sequence(s)

AC166359

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

62640349..62723242 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513867.5 → XP_006513930.1 methylcytosine dioxygenase TET1 isoform X1

See identical proteins and their annotated locations for XP_006513930.1

UniProtKB/TrEMBL

A0A9L6H7S7

Conserved Domains (2) summary

pfam02008
Location:568 → 607

zf-CXXC; CXXC zinc finger domain

cl40427
Location:1371 → 1993

Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
XM_030245174.2 → XP_030101034.1 methylcytosine dioxygenase TET1 isoform X2

Conserved Domains (1) summary

cl40427
Location:717 → 1339

Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins

RNA

XR_003948738.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_027384.1: Suppressed sequence

Description

NM_027384.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.