Stoml1 stomatin like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stoml1provided by RGD
Official Full Name: stomatin like 1provided by RGD
Primary source: RGD:1559463
See related: Ensembl:ENSRNOG00000008530 AllianceGenome:RGD:1559463
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1559463
Summary: Predicted to enable ion channel inhibitor activity. Predicted to act upstream of or within SMAD protein signal transduction; cellular response to leukemia inhibitory factor; and negative regulation of acid-sensing ion channel activity. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Orthologous to human STOML1 (stomatin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 90.1), Lung (RPKM 34.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (67557846..67565734)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (58661980..58669860)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (63037135..63045024)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ion channel inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stomatin-like protein 1

Names: stomatin (EPB72)-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305238.1 → NP_001292167.1 stomatin-like protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6J4Z9, D4A7E9

Related

ENSRNOP00000011383.5, ENSRNOT00000011383.8

Conserved Domains (3) summary

smart00244
Location:77 → 217

PHB; prohibitin homologues

cd13436
Location:94 → 224

SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

pfam02036
Location:304 → 395

SCP2; SCP-2 sterol transfer family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

67557846..67565734

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243184.5 → XP_006243246.1 stomatin-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_006243246.1

UniProtKB/TrEMBL

A6J4Z9

Conserved Domains (3) summary

smart00244
Location:83 → 167

PHB; prohibitin homologues

pfam02036
Location:254 → 345

SCP2; SCP-2 sterol transfer family

cl19107
Location:79 → 174

SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily