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    CG5853 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34322, updated on 10-May-2024

    Summary

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    Official Symbol
    CG5853provided by FlyBase
    Primary source
    FLYBASE:FBgn0032167
    Locus tag
    Dmel_CG5853
    See related
    AllianceGenome:FB:FBgn0032167
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5853
    Summary
    Predicted to enable ATP binding activity; ATP hydrolysis activity; and ATPase-coupled transmembrane transporter activity. Predicted to be active in plasma membrane. Is expressed in adult head; embryonic/larval circulatory system; extended germ band embryo; and yolk nucleus. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to several human genes including ABCG4 (ATP binding cassette subfamily G member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG5853 in Genome Data Viewer
    Location:
    30F1-30F1; 2-38 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9940773..9947648, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9940773..9947648, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Arginine and glutamate rich 1 Neighboring gene antisense RNA:CR45007 Neighboring gene Diadenosine tetraphosphatase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45949 Neighboring gene mir-87 stem loop Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons. Etter PD, et al. BMC Neurosci, 2005 Jun 2. PMID 15932641, Free PMC Article
    2. Integrative genomic analysis reveals novel regulatory mechanisms of eyeless during Drosophila eye development. Yeung K, et al. Nucleic Acids Res, 2018 Dec 14. PMID 30295802, Free PMC Article
    3. Characterization of a novel pesticide transporter and P-glycoprotein orthologues in Drosophila melanogaster. Denecke S, et al. Proc Biol Sci, 2022 May 25. PMID 35582794, Free PMC Article
    4. TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels. Ren Q, et al. Nucleic Acids Res, 2007 Jan. PMID 17135193, Free PMC Article
    5. ATP-Binding Cassette (ABC) Transporter Genes Involved in Pyrethroid Resistance in the Malaria Vector Anopheles sinensis: Genome-Wide Identification, Characteristics, Phylogenetics, and Expression Profile. He Q, et al. Int J Mol Sci, 2019 Mar 20. PMID 30897799, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5853-PA
    CG5853-PB
    CG5853-PC
    NP_001260309.1
    NP_001285786.1
    NP_788019.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9940773..9947648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298857.1 → NP_001285786.1  uncharacterized protein Dmel_CG5853, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285786.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960D7, Q9VL61
      Conserved Domains (3) summary
      cd03213
      Location:102 → 326
      ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
      TIGR00955
      Location:97 → 689
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:420 → 623
      ABC2_membrane; ABC-2 type transporter

    2. NM_001273380.1 → NP_001260309.1  uncharacterized protein Dmel_CG5853, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260309.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960D7, Q9VL61
      Conserved Domains (3) summary
      cd03213
      Location:102 → 326
      ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
      TIGR00955
      Location:97 → 689
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:420 → 623
      ABC2_membrane; ABC-2 type transporter

    3. NM_176005.2 → NP_788019.1  uncharacterized protein Dmel_CG5853, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788019.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960D7, Q9VL61
      Related
      FBpp0079489
      Conserved Domains (3) summary
      cd03213
      Location:102 → 326
      ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
      TIGR00955
      Location:97 → 689
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:420 → 623
      ABC2_membrane; ABC-2 type transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q960D7 Q960D7
    Q9VL61 Q9VL61

    Gene LinkOut

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