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    TMEM216 Transmembrane protein 216 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41035, updated on 10-May-2024

    Summary

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    Official Symbol
    TMEM216provided by FlyBase
    Official Full Name
    Transmembrane protein 216provided by FlyBase
    Primary source
    FLYBASE:FBgn0037614
    Locus tag
    Dmel_CG8116
    See related
    AllianceGenome:FB:FBgn0037614
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8116; Dmel\CG8116; EP(3)3246; GH04517
    Summary
    Predicted to be involved in non-motile cilium assembly. Predicted to be located in cilium. Predicted to be active in ciliary transition zone. Is expressed in organism. Human ortholog(s) of this gene implicated in Joubert syndrome; Joubert syndrome 2; and Meckel syndrome 2. Orthologous to several human genes including TMEM216 (transmembrane protein 216). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See TMEM216 in Genome Data Viewer
    Location:
    85A8-85A9; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8716243..8721320)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4541965..4547042)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene hunchback Neighboring gene Cyclin-dependent kinase subunit 85A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene numerous disordered muscles

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila sensory cilia lacking MKS proteins exhibit striking defects in development but only subtle defects in adults. Pratt MB, et al. J Cell Sci, 2016 Oct 15. PMID 27577095, Free PMC Article
    2. Identification of genes underlying hypoxia tolerance in Drosophila by a P-element screen. Azad P, et al. G3 (Bethesda), 2012 Oct. PMID 23050227, Free PMC Article
    3. Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference. Jankovics F, et al. PLoS One, 2014. PMID 24896584, Free PMC Article
    4. A misexpression study examining dorsal thorax formation in Drosophila melanogaster. Peña-Rangel MT, et al. Genetics, 2002 Mar. PMID 11901120, Free PMC Article
    5. Seizure control through genetic and pharmacological manipulation of Pumilio in Drosophila: a key component of neuronal homeostasis. Lin WH, et al. Dis Model Mech, 2017 Feb 1. PMID 28067623, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 216
    Names
    CG8116-PA
    CG8116-PB
    CG8116-PC
    TMEM216-PA
    TMEM216-PB
    TMEM216-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8716243..8721320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170082.2 → NP_001163553.1  transmembrane protein 216, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHN0
      Conserved Domains (1) summary
      pfam09799
      Location:12 → 115
      Transmemb_17; Predicted membrane protein

    2. NM_141561.4 → NP_649818.1  transmembrane protein 216, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649818.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHN0
      Related
      FBpp0081388
      Conserved Domains (1) summary
      pfam09799
      Location:12 → 115
      Transmemb_17; Predicted membrane protein

    3. NM_001170083.2 → NP_001163554.1  transmembrane protein 216, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163554.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHN0
      Conserved Domains (1) summary
      pfam09799
      Location:12 → 115
      Transmemb_17; Predicted membrane protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHN0 Q9VHN0

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