HP1b Heterochromatin Protein 1b [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: HP1bprovided by FlyBase
Official Full Name: Heterochromatin Protein 1bprovided by FlyBase
Primary source: FLYBASE:FBgn0030082
Locus tag: Dmel_CG7041
See related: AllianceGenome:FB:FBgn0030082
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7041; Dmel\CG7041; HP1; hp1b; Hp1b; HP1B
Summary: Enables chromatin binding activity. Involved in negative regulation of heterochromatin assembly; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in heterochromatin and nucleus. Colocalizes with chromocenter and euchromatin. Is expressed in several structures, including adult head; embryonic brain; gonad; and larval ventral nerve cord. Orthologous to several human genes including CBX3 (chromobox 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 8C4-8C4; 1-26 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (9081063..9082746)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (8975096..8976779)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HP1 associates differently with RNA polymerase II; HP1a and HP1b, but not HP1c, inhibit transcriptional activity, suggesting that HP1c serves as a positive regulator in transcription.
Title: Comparison of three heterochromatin protein 1 homologs in Drosophila.
genes with functions in various metabolic processes are affected primarily by HP1B loss; HP1B is a euchromatic Drosophila HP1 homolog with links to metabolism
Title: HP1B is a euchromatic Drosophila HP1 homolog with links to metabolism.
phenotypes that emerge in the context of wild-type levels of the HP1 and Mod(mdg4) proteins might be part of an adaptive response to the environment.
Title: Chromatin-associated proteins HP1 and Mod(mdg4) modify Y-linked regulatory variation in the drosophila testis.
Data indicate significant similarity and uniqueness in the genes regulated by three HP1 homologs HP1a, HP1b, and HP1c.
Title: DNA microarray profiling of genes differentially regulated by three heterochromatin protein 1 (HP1) homologs in Drosophila.
both activating and repressing roles for HP1 at Sxl(Pe).
Title: Cooperative and antagonistic contributions of two heterochromatin proteins to transcriptional regulation of the Drosophila sex determination decision.
HP1b counteracts HP1a function both in heterochromatin formation and in the transcriptional regulation of euchromatic genes.
Title: Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development.
These observations confirm an HP1 co-operative DNA-binding and display for the first time the HP1 DNA target motif that, we hypothesize, should be one of its nucleation sites.
Title: Heterochromatin protein 1 interacts with 5'UTR of transposable element ZAM in a sequence-specific fashion.
The distribution of the HP1 protein depends on the SuUR gene.
Title: The SuUR gene influences the distribution of heterochromatic proteins HP1 and SU(VAR)3-9 on nurse cell polytene chromosomes of Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromocenter	IDA Inferred from Direct Assay more info	PubMed
part_of euchromatin	IDA Inferred from Direct Assay more info	PubMed
part_of heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of pericentric heterochromatin	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heterochromatin protein 1b

Names: CG7041-PA; CG7041-PB; CG7041-PC; HP1b-PA; HP1b-PB; HP1b-PC; heterochromatin protein 1B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

9081063..9082746

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_132293.3 → NP_572521.2 heterochromatin protein 1b, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572521.2

Status: REVIEWED

UniProtKB/TrEMBL

Q95SE0, Q9W396

Related

FBpp0071221

Conserved Domains (2) summary

smart00298
Location:3 → 52

CHROMO; Chromatin organization modifier domain

pfam01393
Location:100 → 151

Chromo_shadow; Chromo shadow domain
NM_001258657.2 → NP_001245586.1 heterochromatin protein 1b, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245586.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95SE0, Q9W396

Conserved Domains (2) summary

smart00298
Location:3 → 52

CHROMO; Chromatin organization modifier domain

pfam01393
Location:100 → 151

Chromo_shadow; Chromo shadow domain
NM_001169242.2 → NP_001162713.1 heterochromatin protein 1b, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162713.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95SE0, Q9W396

Conserved Domains (2) summary

smart00298
Location:3 → 52

CHROMO; Chromatin organization modifier domain

pfam01393
Location:100 → 151

Chromo_shadow; Chromo shadow domain