Slc25a19 solute carrier family 25 member 19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc25a19provided by RGD
Official Full Name: solute carrier family 25 member 19provided by RGD
Primary source: RGD:1359554
See related: AllianceGenome:RGD:1359554
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable thiamine transmembrane transporter activity. Predicted to be involved in thiamine pyrophosphate transmembrane transport. Predicted to be integral component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in inherited metabolic disorder and microcephaly. Orthologous to human SLC25A19 (solute carrier family 25 member 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 84.4), Thymus (RPKM 83.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (101353426..101366551, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (100853554..100867517, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (104166594..104179523, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-122-5p is involved in posttranscriptional regulation of the mitochondrial thiamin pyrophosphate transporter (SLC25A19) in pancreatic acinar cells.
Title: miR-122-5p is involved in posttranscriptional regulation of the mitochondrial thiamin pyrophosphate transporter (SLC25A19) in pancreatic acinar cells.
mitochondria of Slc25a19(-/-) and Amish lethal microcephaly cells have undetectable and markedly reduced thiamine pyrophosphate content, respectively
Title: Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
NOT enables deoxynucleotide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thiamine pyrophosphate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables thiamine pyrophosphate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thiamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
NOT involved_in deoxynucleotide transport	ISO Inferred from Sequence Orthology more info
involved_in thiamine diphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in thiamine pyrophosphate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in thiamine pyrophosphate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in thiamine pyrophosphate transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial thiamine pyrophosphate carrier

Names: mitochondrial uncoupling protein 1; solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19; solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007674.1 → NP_001007675.1 mitochondrial thiamine pyrophosphate carrier

See identical proteins and their annotated locations for NP_001007675.1

Status: PROVISIONAL

Source sequence(s)

BC079002

UniProtKB/Swiss-Prot

Q6AYL0

UniProtKB/TrEMBL

A0A8L2Q1T4

Conserved Domains (1) summary

pfam00153
Location:118 → 203

Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

101353426..101366551 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269234.1 → XP_063125304.1 mitochondrial thiamine pyrophosphate carrier isoform X1

UniProtKB/Swiss-Prot

Q6AYL0
XM_063269236.1 → XP_063125306.1 mitochondrial thiamine pyrophosphate carrier isoform X1

UniProtKB/Swiss-Prot

Q6AYL0
XM_063269235.1 → XP_063125305.1 mitochondrial thiamine pyrophosphate carrier isoform X1

UniProtKB/Swiss-Prot

Q6AYL0
XM_063269237.1 → XP_063125307.1 mitochondrial thiamine pyrophosphate carrier isoform X2