Bet1l Bet1 golgi vesicular membrane trafficking protein-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bet1lprovided by RGD
Official Full Name: Bet1 golgi vesicular membrane trafficking protein-likeprovided by RGD
Primary source: RGD:71051
See related: Ensembl:ENSRNOG00000013165 AllianceGenome:RGD:71051
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bet1; Gs15
Summary: Predicted to enable SNAP receptor activity. Predicted to be involved in regulation of retrograde vesicle-mediated transport, Golgi to ER and retrograde transport, endosome to Golgi. Located in Golgi apparatus and Golgi-associated vesicle. Is integral component of Golgi membrane. Human ortholog(s) of this gene implicated in uterine fibroid. Orthologous to human BET1L (Bet1 golgi vesicular membrane trafficking protein like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 164.1), Lung (RPKM 140.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (205361041..205365036, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (195931407..195935072, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (213602836..213606507, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that GS15 exists in a distinct SNARE complex that contains syntaxin5, GS28, and Ykt6, and may be involved in both ER-to-Golgi and intra-Golgi transport.
Title: GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNAP receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of retrograde vesicle-mediated transport, Golgi to ER	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of retrograde vesicle-mediated transport, Golgi to ER	IEA Inferred from Electronic Annotation more info
involved_in regulation of retrograde vesicle-mediated transport, Golgi to ER	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi stack	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi stack	ISO Inferred from Sequence Orthology more info
located_in Golgi-associated vesicle	IDA Inferred from Direct Assay more info	PubMed
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BET1-like protein

Names: GOS-15; Golgi soluble N-ethylmaleimide-sensitive factor attachment protein 15; blocked early in transport 1 homolog like; golgi SNARE with a size of 15 kDa; golgi SNARE, 15 kD; vesicle transport protein GOS15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.