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    Spn28B Serpin 28B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34035, updated on 10-May-2024

    Summary

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    Official Symbol
    Spn28Bprovided by FlyBase
    Official Full Name
    Serpin 28Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0083141
    Locus tag
    Dmel_CG6717
    See related
    AllianceGenome:FB:FBgn0083141
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6717; Dmel\CG6717; Spn7
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in multicellular organism reproduction. Located in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); lung disease (multiple); and thrombophilia (multiple). Orthologous to several human genes including SERPINC1 (serpin family C member 1) and SERPINI1 (serpin family I member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Spn28B in Genome Data Viewer
    Location:
    28B3-28B3; 2-27 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7581924..7583333)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7581924..7583333)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Rap GTPase activating protein 1 Neighboring gene long non-coding RNA:CR44082 Neighboring gene long non-coding RNA:CR46063 Neighboring gene long non-coding RNA:CR46535 Neighboring gene long non-coding RNA:CR45370

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin. Richer MJ, et al. Proc Natl Acad Sci U S A, 2004 Jul 20. PMID 15247425, Free PMC Article
    2. Spatial regulation of developmental signaling by a serpin. Hashimoto C, et al. Dev Cell, 2003 Dec. PMID 14667416
    3. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
    4. Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. Garrett M, et al. BMC Genomics, 2009 Oct 22. PMID 19849829, Free PMC Article
    5. Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates. Xu X, et al. BMC Genomics, 2006 Oct 4. PMID 17020603, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serpin 28B
    Names
    CG6717-PA
    CG6717-PB
    Spn28B-PA
    Spn28B-PB
    serine protease inhibitor 7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7581924..7583333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135284.3 → NP_609128.2  serpin 28B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609128.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8F4V2, Q9VLZ8
      Conserved Domains (1) summary
      cd00172
      Location:17 → 373
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    2. NM_001273280.1 → NP_001260209.1  serpin 28B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260209.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8F4V2, Q9VLZ8
      Conserved Domains (1) summary
      cd00172
      Location:17 → 373
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLZ8 Q9VLZ8

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