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    Glo1 Glyoxalase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35656, updated on 10-May-2024

    Summary

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    Official Symbol
    Glo1provided by FlyBase
    Official Full Name
    Glyoxalase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0283450
    Locus tag
    Dmel_CG1707
    See related
    AllianceGenome:FB:FBgn0283450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1707; Dmel\CG1707; glo1
    Summary
    Enables lactoylglutathione lyase activity. Involved in regulation of insulin receptor signaling pathway. Is expressed in adult head and organism. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Glo1 in Genome Data Viewer
    Location:
    43B2-43B2; 2-56 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7393546..7395932, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3281051..3283437, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene costa Neighboring gene DEAH-box helicase 15 Neighboring gene Gustatory receptor 43a Neighboring gene antisense RNA:CR44201 Neighboring gene ELL-associated factor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies. Vicente Miranda H, et al. Brain, 2017 May 1. PMID 28398476
    2. Loxl2 is a mediator of cardiac aging in Drosophila melanogaster, genetically examining the role of aging clock genes. Bouska MJ, et al. G3 (Bethesda), 2022 Jan 4. PMID 34734976, Free PMC Article
    3. Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes. Moraru A, et al. Cell Metab, 2018 Apr 3. PMID 29551588
    4. Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification. Pfaff DH, et al. J Biol Chem, 2017 Jan 13. PMID 27903648, Free PMC Article
    5. Fatty acid synthase cooperates with glyoxalase 1 to protect against sugar toxicity. Garrido D, et al. PLoS Genet, 2015 Feb. PMID 25692475, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lactoylglutathione lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lactoylglutathione lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lactoylglutathione lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glyoxalase 1
    Names
    CG1707-PA
    Glo1-PA
    NP_610270.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7393546..7395932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136426.3 → NP_610270.1  glyoxalase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610270.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6X6
      Related
      FBpp0088085
      Conserved Domains (1) summary
      cl14632
      Location:15 → 173
      Glo_EDI_BRP_like; This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z6X6 A1Z6X6
    Q8MYU8 Q8MYU8

    Gene LinkOut

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