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    MED28 Mediator complex subunit 28 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43079, updated on 10-May-2024

    Summary

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    Official Symbol
    MED28provided by FlyBase
    Official Full Name
    Mediator complex subunit 28provided by FlyBase
    Primary source
    FLYBASE:FBgn0039337
    Locus tag
    Dmel_CG5121
    See related
    AllianceGenome:FB:FBgn0039337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM31575; CG5121; dMED23; Dmel\CG5121; Med23; Med28
    Summary
    Predicted to contribute to transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Part of mediator complex. Orthologous to human MED28 (mediator complex subunit 28). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See MED28 in Genome Data Viewer
    Location:
    96E1-96E1; 3-88 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25477003..25477745)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21302725..21303467)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Furin 1 Neighboring gene Mucin 96D Neighboring gene Vacuolar protein sorting 33B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene XNP

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The chromatin remodelling factor dATRX is involved in heterochromatin formation. Bassett AR, et al. PLoS One, 2008 May 7. PMID 18461125, Free PMC Article
    2. Tousled-like kinase mediated a new type of cell death pathway in Drosophila. Zhang Y, et al. Cell Death Differ, 2016 Jan. PMID 26088162, Free PMC Article
    3. Differential Requirements for Mediator Complex Subunits in Drosophila melanogaster Host Defense Against Fungal and Bacterial Pathogens. Huang C, et al. Front Immunol, 2020. PMID 33746938, Free PMC Article
    4. MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators. Kim TW, et al. Proc Natl Acad Sci U S A, 2004 Aug 17. PMID 15297616, Free PMC Article
    5. A behavioral screen for mediators of age-dependent TDP-43 neurodegeneration identifies SF2/SRSF1 among a group of potent suppressors in both neurons and glia. Azpurua J, et al. PLoS Genet, 2021 Nov. PMID 34723963, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mediator subunits MED16 and MED23 interact with specific activators to coordinate and transfer activator-specific signals to the transcriptional machinery.
      Title: MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to transcription coregulator activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator complex subunit 28
    Names
    CG5121-PA
    MED28-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25477003..25477745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143140.1 → NP_651397.1  mediator complex subunit 28 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651397.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VBQ9
      Related
      FBpp0084211, FBtr0084836
      Conserved Domains (1) summary
      pfam11594
      Location:39 → 130
      Med28; Mediator complex subunit 28
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBQ9.1 Q9VBQ9

    Gene LinkOut

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