Sec61alpha Sec61 alpha subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sec61alphaprovided by FlyBase
Official Full Name: Sec61 alpha subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0086357
Locus tag: Dmel_CG9539
See related: AllianceGenome:FB:FBgn0086357
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0455; anon-WO0118547.195; anon-WO0118547.277; BcDNA:LD29847; BEST:LD29847; CG9539; Dmel\CG9539; dSEC61A; dSec61alpha; DSec61alpha; E(br)165; endd2; l(2)k04917; LD29847; sec61; Sec61; Sec61-alpha; SEC61-alpha; Sec61a; sec61alpha; SEC61ALPHA
Summary: Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; positive regulation of iron ion transmembrane transport; and positive regulation of viral entry into host cell. Located in fusome and rough endoplasmic reticulum. Is expressed in several structures, including adult head; embryonic/larval salivary gland; extended germ band embryo; gonad; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in familial juvenile hyperuricemic nephropathy. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1) and SEC61A2 (SEC61 translocon subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 26D7-26D8; 2-20 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6477182..6480575, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6477182..6480575, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

dorsal closure is rescued in Sec61alpha mutant embryos by an activated form of the Dpp receptor Thick veins
Title: Sec61alpha is required for dorsal closure during Drosophila embryogenesis through its regulation of Dpp signaling.
Loss-of-function experiments for DSec61alpha revealed that the translocon contributes to expanded polyglutamine-mediated neuronal toxicity
Title: Cytosol-endoplasmic reticulum interplay by Sec61alpha translocon in polyglutamine-mediated neurotoxicity in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables signal sequence binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of iron ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of viral entry into host cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-translational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Sec61 translocon complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	HDA more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in fusome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in rough endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Sec61 alpha subunit

Names: CG9539-PA; CG9539-PB; E(br)165; Sec61alpha-PA; Sec61alpha-PB; effector for neural death and degeneration 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

6477182..6480575 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298745.1 → NP_001285674.1 Sec61 alpha subunit, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285674.1

Status: REVIEWED

UniProtKB/TrEMBL

F0JAP1, Q8STG9, Q9VMD1

Conserved Domains (1) summary

PTZ00219
Location:1 → 469

PTZ00219; Sec61 alpha subunit; Provisional
NM_135190.5 → NP_609034.1 Sec61 alpha subunit, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609034.1

Status: REVIEWED

UniProtKB/TrEMBL

F0JAP1, Q8STG9, Q9VMD1

Related

FBpp0078896

Conserved Domains (1) summary

PTZ00219
Location:1 → 469

PTZ00219; Sec61 alpha subunit; Provisional