Rgs8 regulator of G-protein signaling 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgs8provided by MGI
Official Full Name: regulator of G-protein signaling 8provided by MGI
Primary source: MGI:MGI:108408
See related: Ensembl:ENSMUSG00000042671 AllianceGenome:MGI:108408
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6530413N01Rik
Summary: Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Predicted to be involved in G protein-coupled acetylcholine receptor signaling pathway; positive regulation of GTPase activity; and regulation of dopamine receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in dendrite; neuronal cell body membrane; and nucleus. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in central nervous system and retina. Orthologous to human RGS8 (regulator of G protein signaling 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 84.0), cortex adult (RPKM 9.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G3; 1 65.41 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (153528612..153573415)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (153652959..153697669)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings suggest that RGS8 participates in modulation of depression-like behavior
Title: Depression-resistant Phenotype in Mice Overexpressing Regulator of G Protein Signaling 8 (RGS8).
the crystal structure of RGS8 was determined in complex with Galphaq.
Title: Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: MOLECULAR BASIS FOR Gα SELECTIVITY.
ATXN2 interacted selectively with RGS8 mRNA. This interaction was impaired when ATXN2 harbored an expanded polyglutamine. Mutant ATXN2 also reduced RGS8 expression in an in vitro coupled translation
Title: Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model.
increased miR-150 levels in Spinocerebellar ataxia type 1 Purkinje neurons may modulate disease pathogenesis by targeting the expression of Rgs8 and Vegfa.
Title: Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
RGS8 null mutant mice were viable, fertile and showed apparently normal development
Title: Generation of RGS8 null mutant mice by Cre/loxP system.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142761 (e-PCR)
- UniSTS:232008

D1Mit104 (e-PCR), detects polymorphism
- UniSTS:128440

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: regulator of G-protein signaling 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347115.1 → NP_001334044.1 regulator of G-protein signaling 8 isoform 2

Status: VALIDATED

Source sequence(s)

AC154140, CF741546

Consensus CDS

CCDS83607.1

UniProtKB/TrEMBL

D3Z289

Related

ENSMUSP00000107445.2, ENSMUST00000111814.8

Conserved Domains (1) summary

cd08711
Location:44 → 168

RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
NM_001357525.1 → NP_001344454.1 regulator of G-protein signaling 8 isoform 1

Status: VALIDATED

Source sequence(s)

AC154140

Consensus CDS

CCDS15375.1

UniProtKB/Swiss-Prot

Q505F2, Q8BXT1

Related

ENSMUSP00000107443.2, ENSMUST00000111812.8

Conserved Domains (1) summary

cd08711
Location:46 → 170

RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
NM_026380.3 → NP_080656.2 regulator of G-protein signaling 8 isoform 1

See identical proteins and their annotated locations for NP_080656.2

Status: VALIDATED

Source sequence(s)

BC065056, BY292997

Consensus CDS

CCDS15375.1

UniProtKB/Swiss-Prot

Q505F2, Q8BXT1

Related

ENSMUSP00000045715.6, ENSMUST00000041776.12

Conserved Domains (1) summary

cd08711
Location:46 → 170

RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

153528612..153573415

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529822.5 → XP_006529885.1 regulator of G-protein signaling 8 isoform X2

See identical proteins and their annotated locations for XP_006529885.1

UniProtKB/TrEMBL

D3Z289

Conserved Domains (1) summary

cd08711
Location:44 → 168

RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
XM_006529829.5 → XP_006529892.1 regulator of G-protein signaling 8 isoform X3

Conserved Domains (1) summary

cl02565
Location:10 → 134

RGS; Regulator of G protein signaling (RGS) domain superfamily
XM_006529821.3 → XP_006529884.1 regulator of G-protein signaling 8 isoform X1

See identical proteins and their annotated locations for XP_006529884.1

UniProtKB/Swiss-Prot

Q505F2, Q8BXT1

Conserved Domains (1) summary

cd08711
Location:46 → 170

RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
XM_006529826.4 → XP_006529889.1 regulator of G-protein signaling 8 isoform X2

See identical proteins and their annotated locations for XP_006529889.1

UniProtKB/TrEMBL

D3Z289

Conserved Domains (1) summary

cd08711
Location:44 → 168

RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
XM_030242505.1 → XP_030098365.1 regulator of G-protein signaling 8 isoform X1

UniProtKB/Swiss-Prot

Q505F2, Q8BXT1

Related

ENSMUSP00000107441.2, ENSMUST00000111810.2

Conserved Domains (1) summary

cd08711
Location:46 → 170

RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
XM_006529828.3 → XP_006529891.1 regulator of G-protein signaling 8 isoform X2

See identical proteins and their annotated locations for XP_006529891.1

UniProtKB/TrEMBL

D3Z289

Related

ENSMUSP00000107446.2, ENSMUST00000111815.8

Conserved Domains (1) summary

cd08711
Location:44 → 168

RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
XM_030242507.2 → XP_030098367.1 regulator of G-protein signaling 8 isoform X1

UniProtKB/Swiss-Prot

Q505F2, Q8BXT1

Conserved Domains (1) summary

cd08711
Location:46 → 170

RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
XM_006529827.4 → XP_006529890.1 regulator of G-protein signaling 8 isoform X2

See identical proteins and their annotated locations for XP_006529890.1

UniProtKB/TrEMBL

D3Z289

Conserved Domains (1) summary

cd08711
Location:44 → 168

RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
XM_006529825.4 → XP_006529888.1 regulator of G-protein signaling 8 isoform X2

See identical proteins and their annotated locations for XP_006529888.1

UniProtKB/TrEMBL

D3Z289

Conserved Domains (1) summary

cd08711
Location:44 → 168

RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
XM_006529824.5 → XP_006529887.1 regulator of G-protein signaling 8 isoform X2

See identical proteins and their annotated locations for XP_006529887.1

UniProtKB/TrEMBL

D3Z289

Conserved Domains (1) summary

cd08711
Location:44 → 168

RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
XM_006529818.5 → XP_006529881.1 regulator of G-protein signaling 8 isoform X1

See identical proteins and their annotated locations for XP_006529881.1

UniProtKB/Swiss-Prot

Q505F2, Q8BXT1

Conserved Domains (1) summary

cd08711
Location:46 → 170

RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
XM_006529820.5 → XP_006529883.1 regulator of G-protein signaling 8 isoform X1

See identical proteins and their annotated locations for XP_006529883.1

UniProtKB/Swiss-Prot

Q505F2, Q8BXT1

Conserved Domains (1) summary

cd08711
Location:46 → 170

RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
XM_036153199.1 → XP_036009092.1 regulator of G-protein signaling 8 isoform X3

Conserved Domains (1) summary

cl02565
Location:10 → 134

RGS; Regulator of G protein signaling (RGS) domain superfamily
XM_036153183.1 → XP_036009076.1 regulator of G-protein signaling 8 isoform X1

UniProtKB/Swiss-Prot

Q505F2, Q8BXT1

Conserved Domains (1) summary

cd08711
Location:46 → 170

RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein