Cdadc1 cytidine and dCMP deaminase domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdadc1provided by MGI
Official Full Name: cytidine and dCMP deaminase domain containing 1provided by MGI
Primary source: MGI:MGI:1919141
See related: Ensembl:ENSMUSG00000021982 AllianceGenome:MGI:1919141
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NYD-SP15; 2310010M10Rik
Summary: Predicted to enable several functions, including cytidine deaminase activity; importin-alpha family protein binding activity; and protein homodimerization activity. Predicted to be involved in DNA cytosine deamination and cytidine deamination. Predicted to be located in cytoplasm and nucleus. Orthologous to human CDADC1 (cytidine and dCMP deaminase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 3.1), frontal lobe adult (RPKM 2.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 31.48 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (59796837..59835433, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (59559386..59597985, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NYD-SP15 protein plays an important role in testicular development and spermatogenesis
Title: NYD-SP15: a novel gene potentially involved in regulating testicular development and spermatogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

AI449174 (e-PCR)
- UniSTS:160398

AI463398 (e-PCR)
- UniSTS:160399

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables cytidine deaminase activity	ISO Inferred from Sequence Orthology more info
enables dCMP deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables importin-alpha family protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA cytosine deamination	ISO Inferred from Sequence Orthology more info
involved_in cytidine deamination	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytidine deamination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytidine and dCMP deaminase domain-containing protein 1

Names: cytidine deaminase

NP_001162007.1

EC 3.5.4.5

NP_001162008.1

EC 3.5.4.5

NP_001162009.1

EC 3.5.4.5

NP_001162010.1

EC 3.5.4.5

NP_082262.1

EC 3.5.4.5

XP_011243506.1

EC 3.5.4.5

XP_030103902.1

EC 3.5.4.5

XP_036014747.1

EC 3.5.4.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168535.1 → NP_001162007.1 cytidine and dCMP deaminase domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_001162007.1

Status: VALIDATED

Description

Transcript Variant: This variant represents the longest transcript and it encodes the longest protein (isoform 1).

Source sequence(s)

AC147044, AK032600, AK038926, BE648840, CX242881

Consensus CDS

CCDS49514.1

UniProtKB/TrEMBL

G3UW39

Related

ENSMUSP00000153357.2, ENSMUST00000225839.2

Conserved Domains (2) summary

cd01286
Location:320 → 455

deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

cl00269
Location:83 → 152

cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
NM_001168536.1 → NP_001162008.1 cytidine and dCMP deaminase domain-containing protein 1 isoform 3

See identical proteins and their annotated locations for NP_001162008.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains a different 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus when it is compared to isoform 1.

Source sequence(s)

AK009280, AK039148, CX242881

Consensus CDS

CCDS49515.1

UniProtKB/Swiss-Prot

Q8BMD5

Related

ENSMUSP00000128064.2, ENSMUST00000171683.3

Conserved Domains (2) summary

cd01286
Location:320 → 455

deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

cl00269
Location:83 → 152

cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
NM_001168537.1 → NP_001162009.1 cytidine and dCMP deaminase domain-containing protein 1 isoform 4

See identical proteins and their annotated locations for NP_001162009.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1.

Source sequence(s)

AC147044, AK032600, AK038926, BE648840, CX242881

Consensus CDS

CCDS49513.1

UniProtKB/Swiss-Prot

Q8BMD5

Related

ENSMUSP00000022555.4, ENSMUST00000022555.11

Conserved Domains (2) summary

cd01286
Location:320 → 455

deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

cl00269
Location:83 → 152

cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
NM_001168538.1 → NP_001162010.1 cytidine and dCMP deaminase domain-containing protein 1 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate exon and uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus when it is compared to isoform 1.

Source sequence(s)

AC147044, AK032813, AK039148, CX242881

Consensus CDS

CCDS88678.1

UniProtKB/Swiss-Prot

Q8BMD5

Related

ENSMUSP00000128022.3, ENSMUST00000167100.9

Conserved Domains (2) summary

cd01286
Location:320 → 455

deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

cl00269
Location:83 → 152

cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
NM_027986.3 → NP_082262.1 cytidine and dCMP deaminase domain-containing protein 1 isoform 2

See identical proteins and their annotated locations for NP_082262.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains a different 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.

Source sequence(s)

AK032813, CO039661, CX242881

Consensus CDS

CCDS36940.1

UniProtKB/Swiss-Prot

Q8BMD5, Q8BYL2, Q8BYN1, Q8C014, Q922P4, Q99KL2, Q9D7F3

Related

ENSMUSP00000052233.8, ENSMUST00000056997.15

Conserved Domains (2) summary

cd01286
Location:320 → 455

deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

cl00269
Location:83 → 152

cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

RNA

NR_153387.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC147044, AK032813, AK039148, CX242881

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

59796837..59835433 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245204.4 → XP_011243506.1 cytidine and dCMP deaminase domain-containing protein 1 isoform X1

Conserved Domains (2) summary

cd01286
Location:320 → 455

deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

cl00269
Location:83 → 152

cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
XM_030248042.2 → XP_030103902.1 cytidine and dCMP deaminase domain-containing protein 1 isoform X2

Conserved Domains (1) summary

cl00269
Location:20 → 139

cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
XM_036158854.1 → XP_036014747.1 cytidine and dCMP deaminase domain-containing protein 1 isoform X2

Conserved Domains (1) summary

cl00269
Location:20 → 139

cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...