Cpt1b carnitine palmitoyltransferase 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cpt1bprovided by RGD
Official Full Name: carnitine palmitoyltransferase 1Bprovided by RGD
Primary source: RGD:2397
See related: Ensembl:ENSRNOG00000010438 AllianceGenome:RGD:2397
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CPT-IB; M-CPTI
Summary: Enables carnitine O-palmitoyltransferase activity. Involved in long-chain fatty acid transport. Located in mitochondrion. Orthologous to human CPT1B (carnitine palmitoyltransferase 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 1258.7), Muscle (RPKM 636.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (122370974..122380473, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (120491354..120500833, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (130395211..130404731, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In summary, our results show that oxfenicine-induced inhibition of CPT-1b markedly affects WAT metabolism, leading to reduced adiposity through a mechanism that involves reduced lipogenesis in the SC Ing and Epid fat depots of rats.
Title: Antilipolytic and antilipogenic effects of the CPT-1b inhibitor oxfenicine in the white adipose tissue of rats.
CPT1B was significantly over-expressed in the amygdala and in the blood of stressed rats compared with non-stressed controls.
Title: Mitochondria-focused gene expression profile reveals common pathways and CPT1B dysregulation in both rodent stress model and human subjects with PTSD.
Increased fat accumulation characterizing obesity may be caused by impaired oxidative capacity due to decreased carnitine palmitoyltransferase 1b levels in the white adipose tissue.
Title: Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity.
The ratio of [P-CoA]/[M-CoA] is critical for regulating CPT-I activity & may partially rectify the in vivo disconnect between M-CoA content & CPT-I flux within the context of exercise & Type 2 diabetes.
Title: Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates.
The protein expressions of CPT-I and PPARdelta decreased in excessive fatigue rats.
Title: [Effects of fatigue and restraint stress on the expression of carnitine palmitoyltransferase-I and 5-hydroxytryptamine receptors in aorta of rats].
Supplementation with docosahexaenoic acid during pregnancy could increase carnitine palmitoyl transferase-I gene expression in offspring.
Title: [Effect of pregnancy rats supplemented with docosahexaenoic acid on carnitine palmitoyl transferase-I gene expression in offspring].
Carnitine palmitoyl transferase 1 had a 47% decrease in untreated diabetic rats, which was normalized by insulin
Title: Increased carnitine palmitoyl transferase 1 expression and decreased sterol regulatory element-binding protein 1c expression are associated with reduced intramuscular triglyceride accumulation after insulin therapy in high-fat-diet and streptozotocin-induced diabetic rats.
a novel region in the first exon/intron of the CPT-Ibeta gene acts as a non-classical transcriptional enhancer
Title: A region in the first exon/intron of rat carnitine palmitoyltransferase Ibeta is involved in enhancement of basal transcription.
Genetic analysis, comparison, and tissue distribution of CPT1b
Title: Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals.
muscle CPTI has high malonyl-CoA sensitivity
Title: A single amino acid change (substitution of the conserved Glu-590 with alanine) in the C-terminal domain of rat liver carnitine palmitoyltransferase I increases its malonyl-CoA sensitivity close to that observed with the muscle isoform of the enzyme.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

D7Wox44 (e-PCR)
- UniSTS:518665

MARC_16689-16690:1017862088:1 (e-PCR)
- UniSTS:268074

Chetk (e-PCR)
- UniSTS:261874

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carnitine O-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carnitine O-palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables carnitine O-palmitoyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables carnitine O-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in carnitine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in carnitine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in response to blue light	ISO Inferred from Sequence Orthology more info
involved_in response to blue light	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carnitine O-palmitoyltransferase 1, muscle isoform

Names: CPT I; CPT-Ibeta 1; CPT-Ibeta 3; CPT1-M; CPTI-M; Carnitine palmitoyltransferase 1, muscle; carnitine palmitoyltransferase 1b, muscle; carnitine palmitoyltransferase I-like protein; carnitine palmitoyltransferase Ibeta 1; carnitine palmitoyltransferase Ibeta 2; carnitine palmitoyltransferase Ibeta 3

NP_037332.2

EC 2.3.1.21

XP_006242242.1

EC 2.3.1.21

XP_038934430.1

EC 2.3.1.21

XP_063119136.1

EC 2.3.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013200.2 → NP_037332.2 carnitine O-palmitoyltransferase 1, muscle isoform

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q63704

UniProtKB/TrEMBL

A6K7M6, O70253

Related

ENSRNOP00000013985.2, ENSRNOT00000013985.4

Conserved Domains (2) summary

pfam00755
Location:173 → 761

Carn_acyltransf; Choline/Carnitine o-acyltransferase

pfam16484
Location:1 → 47

CPT_N; Carnitine O-palmitoyltransferase N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

122370974..122380473 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263066.1 → XP_063119136.1 carnitine O-palmitoyltransferase 1, muscle isoform isoform X2

UniProtKB/Swiss-Prot

Q63704

UniProtKB/TrEMBL

A6K7M6, O70253
XM_006242180.5 → XP_006242242.1 carnitine O-palmitoyltransferase 1, muscle isoform isoform X1

UniProtKB/TrEMBL

O70253

Conserved Domains (2) summary

pfam00755
Location:173 → 764

Carn_acyltransf; Choline/Carnitine o-acyltransferase

pfam16484
Location:1 → 47

CPT_N; Carnitine O-palmitoyltransferase N-terminus
XM_039078502.1 → XP_038934430.1 carnitine O-palmitoyltransferase 1, muscle isoform isoform X1

UniProtKB/TrEMBL

O70253

Conserved Domains (2) summary

pfam00755
Location:173 → 764

Carn_acyltransf; Choline/Carnitine o-acyltransferase

pfam16484
Location:1 → 47

CPT_N; Carnitine O-palmitoyltransferase N-terminus