Slc25a1 solute carrier family 25 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc25a1provided by RGD
Official Full Name: solute carrier family 25 member 1provided by RGD
Primary source: RGD:3703
See related: Ensembl:ENSRNOG00000038001 AllianceGenome:RGD:3703
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cic; Ctp; Slc20a3
Summary: This gene encodes a member of the mitochondrial carrier family. The encoded protein is responsible for the movement of tricarboxylates, such as citrate, across the inner mitochondrial membrane. It is essential to the bioenergetics of hepatic cells, supplying the cytoplasm with a carbon source for fatty acid and sterol biosynthesis, and NAD+ for the glycolytic pathway. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Adrenal (RPKM 232.3), Liver (RPKM 220.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (96560054..96563071)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (83055764..83058781)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (87204248..87207265)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

binding of PPRE of CiC promoter by PPARalpha and PPARgammain vivo
Title: Citrate carrier promoter is target of peroxisome proliferator-activated receptor alpha and gamma in hepatocytes and adipocytes.
Data show that under conditions of increased ionic strength, the citrate carrier precursor protein presequence binds to Tom20 and accumulates at the mitochondrial surface.
Title: Import of rat mitochondrial citrate carrier (CIC) at increasing salt concentrations promotes presequence binding to import receptor Tom20 and inhibits membrane translocation.
Results suggest that in starved rats the regulation of hepatic citrate carrier expression occurs at posttranscriptional level.
Title: Starvation-induced posttranscriptional control of rat liver mitochondrial citrate carrier expression.
administration of n-6 PUFAs to rats leads to changes not only in the transcriptional rate of the tricarboxylate (citrate) carrier gene but also in the processing of the nuclear precursor for TCC RNA.
Title: n-6 PUFAs downregulate expression of the tricarboxylate carrier in rat liver by transcriptional and posttranscriptional mechanisms.
that export of citrate and/or isocitrate from the mitochondria to the cytosol through Slc25a1 is an important step in control of glucose-stimulated insulin secretion
Title: The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.
Different dietary fatty acids have dissimilar effects on activity and gene expression of Ctp.
Title: Different dietary fatty acids have dissimilar effects on activity and gene expression of mitochondrial tricarboxylate carrier in rat liver.
Data show that the citrate carrier (CIC) presequence was found to be dispensable both for targeting to mitochondria and insertion into the inner membrane.
Title: Biogenesis of rat mitochondrial citrate carrier (CIC): the N-terminal presequence facilitates the solubility of the preprotein but does not act as a targeting signal.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc25a1 (e-PCR), detects polymorphism
- UniSTS:265747

Es2el (e-PCR), detects polymorphism
- UniSTS:260490

NoName (e-PCR)
- UniSTS:547032

Slc25a1 (e-PCR), detects polymorphism
- UniSTS:547032

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables citrate secondary active transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables citrate secondary active transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables citrate secondary active transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables citrate transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables tricarboxylic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitochondrial citrate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial citrate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial citrate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial citrate transmembrane transport	TAS Traceable Author Statement more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tricarboxylate transport protein, mitochondrial

Names: citrate carrier; citrate transport protein; citrate transporter) member 1; mitochondrial tricarboxylate carrier; solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017307.3 → NP_059003.1 tricarboxylate transport protein, mitochondrial precursor

See identical proteins and their annotated locations for NP_059003.1

Status: REVIEWED

Source sequence(s)

BC100077, CB758644

UniProtKB/Swiss-Prot

P32089, Q498T8

UniProtKB/TrEMBL

A0A8I6AEC6, A6JSJ3

Related

ENSRNOP00000000306.5, ENSRNOT00000000306.6

Conserved Domains (2) summary

PTZ00169
Location:30 → 304

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:24 → 114

Mito_carr; Mitochondrial carrier protein