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    Dact2 dishevelled-binding antagonist of beta-catenin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308212, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Dact2provided by RGD
    Official Full Name
    dishevelled-binding antagonist of beta-catenin 2provided by RGD
    Primary source
    RGD:1310742
    See related
    Ensembl:ENSRNOG00000022921 AllianceGenome:RGD:1310742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including beta-catenin binding activity; delta-catenin binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including epithelial cell morphogenesis; inner medullary collecting duct development; and negative regulation of nodal signaling pathway. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in cytoplasm. Orthologous to human DACT2 (dishevelled binding antagonist of beta catenin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 54.1), Brain (RPKM 37.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dact2 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (63854182..63864153, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (55181023..55191026, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (56159435..56169443, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485083 Neighboring gene FERM domain containing 1 Neighboring gene SPARC related modular calcium binding 2 Neighboring gene transfer RNA proline (anticodon AGG) 46 Neighboring gene thrombospondin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mechanism of dact2 gene inhibiting the occurrence and development of liver fibrosis. Huang S, et al. Cell Mol Biol (Noisy-le-grand), 2022 Feb 27. PMID 35818217
    2. Dact2 is expressed in the developing ureteric bud/collecting duct system of the kidney and controls morphogenetic behavior of collecting duct cells. Lee WC, et al. Am J Physiol Renal Physiol, 2010 Oct. PMID 20685821
    3. Accelerated re-epithelialization in Dpr2-deficient mice is associated with enhanced response to TGFbeta signaling. Meng F, et al. J Cell Sci, 2008 Sep 1. PMID 18716284
    4. The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling. Su Y, et al. FASEB J, 2007 Mar. PMID 17197390
    5. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. Kivimäe S, et al. BMC Biochem, 2011 Jun 30. PMID 21718540, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanism of dact2 gene inhibiting the occurrence and development of liver fibrosis.
      Title: Mechanism of dact2 gene inhibiting the occurrence and development of liver fibrosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables delta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inner medullary collecting duct development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nodal signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of nodal signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skin development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dapper homolog 2
    Names
    dapper homolog 2, antagonist of beta-catenin
    dapper, antagonist of beta-catenin, homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107464.3 → NP_001100934.2  dapper homolog 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6KB18, D3ZSK6
      Related
      ENSRNOP00000030909.4, ENSRNOT00000035125.6
      Conserved Domains (1) summary
      pfam15268
      Location:19 → 768
      Dapper; Dapper

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      63854182..63864153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110742.2 → XP_038966670.1  dapper homolog 2 isoform X1

      UniProtKB/TrEMBL
      A6KB18
      Conserved Domains (1) summary
      pfam15268
      Location:42 → 746
      Dapper

    2. XM_006227965.5 → XP_006228027.1  dapper homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K7K6
      Related
      ENSRNOP00000074246.2
      Conserved Domains (1) summary
      pfam15268
      Location:17 → 712
      Dapper; Dapper

    3. XM_006227964.5 → XP_006228026.1  dapper homolog 2 isoform X4

      Conserved Domains (1) summary
      pfam15268
      Location:2 → 719
      Dapper; Dapper

    4. XM_017589095.3 → XP_017444584.1  dapper homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNT5
      Conserved Domains (1) summary
      pfam15268
      Location:32 → 727
      Dapper; Dapper

    5. XM_039110765.2 → XP_038966693.1  dapper homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGU3
      Conserved Domains (1) summary
      pfam15268
      Location:25 → 724
      Dapper

    6. XM_006227962.4 → XP_006228024.1  dapper homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGU3
      Related
      ENSRNOP00000092293.1
      Conserved Domains (1) summary
      pfam15268
      Location:25 → 724
      Dapper

    7. XM_006227960.5 → XP_006228022.1  dapper homolog 2 isoform X2

      See identical proteins and their annotated locations for XP_006228022.1

      UniProtKB/TrEMBL
      A0A8I5ZNT5
      Related
      ENSRNOP00000078658.1
      Conserved Domains (1) summary
      pfam15268
      Location:32 → 727
      Dapper; Dapper
    Nucleotide Protein Strain
    Heading Accession and Version

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