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    Ncaph2 non-SMC condensin II complex, subunit H2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300149, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ncaph2provided by RGD
    Official Full Name
    non-SMC condensin II complex, subunit H2provided by RGD
    Primary source
    RGD:1565937
    See related
    Ensembl:ENSRNOG00000009598 AllianceGenome:RGD:1565937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in meiotic chromosome condensation and nuclear division. Predicted to act upstream of or within T cell differentiation in thymus. Predicted to be located in several cellular components, including condensed chromosome; intercellular bridge; and nucleoplasm. Predicted to be part of condensin complex. Predicted to be active in chromosome and nucleus. Orthologous to human NCAPH2 (non-SMC condensin II complex subunit H2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 282.0), Liver (RPKM 245.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ncaph2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122302550..122319570)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120422926..120439942)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130326597..130343655)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene lipase maturation factor 2 Neighboring gene thymidine phosphorylase Neighboring gene ciliary microtubule associated protein 1B Neighboring gene kelch domain containing 7B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell development. Gosling KM, et al. Proc Natl Acad Sci U S A, 2007 Jul 24. PMID 17640884, Free PMC Article
    2. Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability. Woodward J, et al. Genes Dev, 2016 Oct 1. PMID 27737961, Free PMC Article
    3. Condensin confers the longitudinal rigidity of chromosomes. Houlard M, et al. Nat Cell Biol, 2015 Jun. PMID 25961503, Free PMC Article
    4. Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis. Martin CA, et al. Genes Dev, 2016 Oct 1. PMID 27737959, Free PMC Article
    5. Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. Nishide K, et al. PLoS Genet, 2014 Dec. PMID 25474630, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114417

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within T cell differentiation in thymus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in female meiosis chromosome separation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in female meiosis chromosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in female meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic chromosome condensation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic sister chromatid separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid separation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chromosome separation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of chromosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed nuclear chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of condensin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of condensin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    condensin-2 complex subunit H2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024877.2 → NP_001020048.1  condensin-2 complex subunit H2 isoform 2

      See identical proteins and their annotated locations for NP_001020048.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q4V8I2
      UniProtKB/TrEMBL
      A0A8L2QQZ1
      Related
      ENSRNOP00000052664.3, ENSRNOT00000055808.3
      Conserved Domains (3) summary
      pfam06278
      Location:1 → 73
      CNDH2_N; Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
      pfam16858
      Location:255 → 536
      CNDH2_C; Condensin II complex subunit CAP-H2 or CNDH2, C-term
      pfam16869
      Location:97 → 207
      CNDH2_M; PF16858

    2. NM_001399741.1 → NP_001386670.1  condensin-2 complex subunit H2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2K4H8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      122302550..122319570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242186.5 → XP_006242248.1  condensin-2 complex subunit H2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4H8
      Conserved Domains (3) summary
      pfam06278
      Location:11 → 123
      CNDH2_N; Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
      pfam16858
      Location:305 → 587
      CNDH2_C; Condensin II complex subunit CAP-H2 or CNDH2, C-term
      pfam16869
      Location:147 → 257
      CNDH2_M; PF16858

    2. XM_063263347.1 → XP_063119417.1  condensin-2 complex subunit H2 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QQZ1

    3. XM_006242188.5 → XP_006242250.1  condensin-2 complex subunit H2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QQZ1
      Conserved Domains (3) summary
      pfam06278
      Location:26 → 115
      CNDH2_N; Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
      pfam16858
      Location:297 → 579
      CNDH2_C; Condensin II complex subunit CAP-H2 or CNDH2, C-term
      pfam16869
      Location:139 → 249
      CNDH2_M; PF16858
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8I2.1 GenPept UniProtKB/Swiss-Prot:Q4V8I2

    Gene LinkOut

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