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    Kcnk12 potassium channel, subfamily K, member 12 [ Mus musculus (house mouse) ]

    Gene ID: 210741, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Kcnk12provided by MGI
    Official Full Name
    potassium channel, subfamily K, member 12provided by MGI
    Primary source
    MGI:MGI:2684043
    See related
    Ensembl:ENSMUSG00000050138 AllianceGenome:MGI:2684043
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mntk1
    Summary
    Predicted to enable potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be integral component of plasma membrane. Orthologous to human KCNK12 (potassium two pore domain channel subfamily K member 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 13.2), ovary adult (RPKM 10.6) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcnk12 in Genome Data Viewer
    Location:
    17 E4; 17 57.87 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (88049100..88106329, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (87745821..87797994, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene epithelial cell adhesion molecule Neighboring gene STARR-seq mESC enhancer starr_43514 Neighboring gene STARR-positive B cell enhancer ABC_E7565 Neighboring gene STARR-seq mESC enhancer starr_43516 Neighboring gene mutS homolog 2 Neighboring gene STARR-seq mESC enhancer starr_43518 Neighboring gene STARR-seq mESC enhancer starr_43519 Neighboring gene STARR-seq mESC enhancer starr_43521 Neighboring gene predicted gene, 41649 Neighboring gene STARR-seq mESC enhancer starr_43523 Neighboring gene STARR-seq mESC enhancer starr_43524 Neighboring gene STARR-seq mESC enhancer starr_43525 Neighboring gene STARR-seq mESC enhancer starr_43526 Neighboring gene STARR-seq mESC enhancer starr_43527 Neighboring gene ribosomal protein L36, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney. Theilig F, et al. Cell Physiol Biochem, 2008. PMID 18209473
    2. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Harrell MD, et al. Physiol Genomics, 2007 Feb 12. PMID 16985003
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney.
      Title: Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stabilization of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    potassium channel subfamily K member 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199251.1 → NP_954859.1  potassium channel subfamily K member 12

      See identical proteins and their annotated locations for NP_954859.1

      Status: VALIDATED

      Source sequence(s)
      AB052939
      Consensus CDS
      CCDS29020.1
      UniProtKB/TrEMBL
      Q76M80
      Related
      ENSMUSP00000053595.8, ENSMUST00000055221.9
      Conserved Domains (1) summary
      pfam07885
      Location:222 → 304
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      88049100..88106329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160433.1 → XP_036016326.1  potassium channel subfamily K member 12 isoform X1

      Conserved Domains (1) summary
      pfam07885
      Location:116 → 198
      Ion_trans_2; Ion channel

    2. XM_036160434.1 → XP_036016327.1  potassium channel subfamily K member 12 isoform X2

      Conserved Domains (1) summary
      pfam07885
      Location:89 → 171
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version

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