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    Pip4p2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [ Mus musculus (house mouse) ]

    Gene ID: 72519, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pip4p2provided by MGI
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2provided by MGI
    Primary source
    MGI:MGI:1919769
    See related
    Ensembl:ENSMUSG00000028221 AllianceGenome:MGI:1919769
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem55a; 2610319K07Rik
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. Involved in negative regulation of phagocytosis and phosphatidylinositol dephosphorylation. Located in late endosome membrane; phagocytic vesicle membrane; and plasma membrane. Orthologous to human PIP4P2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 23.5), CNS E11.5 (RPKM 19.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pip4p2 in Genome Data Viewer
    Location:
    4 A1; 4 6.41 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (14864219..14915501)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (14864219..14915260)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 69 Neighboring gene STARR-seq mESC enhancer starr_09637 Neighboring gene STARR-positive B cell enhancer ABC_E6153 Neighboring gene OTU domain containing 6B Neighboring gene predicted gene 11837 Neighboring gene STARR-seq mESC enhancer starr_09640 Neighboring gene N-terminal EF-hand calcium binding protein 1 Neighboring gene predicted gene 11844

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis. Morioka S, et al. J Cell Sci, 2018 Mar 6. PMID 29378918
    2. Ash2l interacts with Tbx1 and is required during early embryogenesis. Stoller JZ, et al. Exp Biol Med (Maywood), 2010 May. PMID 20463296, Free PMC Article
    3. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagocytic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    Names
    ptdIns-4,5-P2 4-Ptase II
    transmembrane protein 55A
    type 2 PtdIns-4,5-P2 4-Ptase
    type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    NP_001406160.1
    NP_082540.1
    XP_036020355.1
    XP_036020356.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419231.1 → NP_001406160.1  type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL831792

    2. NM_028264.5 → NP_082540.1  type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 1

      See identical proteins and their annotated locations for NP_082540.1

      Status: VALIDATED

      Source sequence(s)
      AL831792
      Consensus CDS
      CCDS17981.1
      UniProtKB/Swiss-Prot
      Q9CZX7
      Related
      ENSMUSP00000029875.4, ENSMUST00000029875.4
      Conserved Domains (1) summary
      pfam09788
      Location:7 → 250
      Tmemb_55A; Transmembrane protein 55A

    RNA

    1. NR_185048.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL831792

    2. NR_185049.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL831792

    3. NR_185050.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL831792

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      14864219..14915501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164462.1 → XP_036020355.1  type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1

      Conserved Domains (1) summary
      pfam09788
      Location:19 → 147
      Tmemb_55A; Transmembrane protein 55A

    2. XM_036164463.1 → XP_036020356.1  type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1

      Conserved Domains (1) summary
      pfam09788
      Location:19 → 147
      Tmemb_55A; Transmembrane protein 55A
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZX7.1 GenPept UniProtKB/Swiss-Prot:Q9CZX7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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