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    Tfpi tissue factor pathway inhibitor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29436, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Tfpiprovided by RGD
    Official Full Name
    tissue factor pathway inhibitorprovided by RGD
    Primary source
    RGD:61914
    See related
    Ensembl:ENSRNOG00000005039 AllianceGenome:RGD:61914
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in cellular response to interleukin-1; cellular response to lipopolysaccharide; and response to estradiol. Located in extracellular space. Biomarker of atrial fibrillation; disseminated intravascular coagulation; myocardial infarction; and osteonecrosis. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 279.1), Lung (RPKM 156.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tfpi in Genome Data Viewer
    Location:
    3q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (89939862..89989253, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (69533156..69582547, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (71852738..71902127, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486293 Neighboring gene calcitonin receptor like receptor Neighboring gene uncharacterized LOC134486403 Neighboring gene uncharacterized LOC134486404 Neighboring gene uncharacterized LOC108350412

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effect of nitric oxide deficiency on tissue-type plasminogen activator expression in the umbilical cord in a pregnancy-induced hypertension rat model. Mukai Y, et al. Pregnancy Hypertens, 2012 Jan. PMID 26104991
    2. Tissue factor pathway inhibitor in activated prothrombin complex concentrates (aPCC) moderates the effectiveness of therapy in some severe hemophilia A patients with inhibitor. Ogiwara K, et al. Int J Hematol, 2014. PMID 24687919
    3. Drug-drug interaction of the anti-TFPI aptamer BAX499 and factor VIII: studies of spatial dynamics of fibrin clot formation in hemophilia A. Parunov LA, et al. Thromb Res, 2014 Jan. PMID 24263002
    4. Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. Rancourt RC, et al. Toxicol Appl Pharmacol, 2013 Oct 1. PMID 23727623, Free PMC Article
    5. TFPI resistance related to inherited or acquired protein S deficiency. Tardy-Poncet B, et al. Thromb Res, 2012 Dec. PMID 23079294

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Intersection of regulatory pathways controlling hemostasis and hemochorial placentation.
      Title: Intersection of regulatory pathways controlling hemostasis and hemochorial placentation.
    2. Treatment with irbesartan plus carvedilol reduced the expression of TF and TFPI mRNA and protein after myocardial infarction in rats.
      Title: Combined effects of irbesartan and carvedilol on expression of tissue factor and tissue factor pathway inhibitor in rats after myocardial infarction.
    3. analysis of tissue factor changes and the effects of tissue factor pathway inhibitor on transient focal cerebral ischemia in rats
      Title: Changes in tissue factor and the effects of tissue factor pathway inhibitor on transient focal cerebral ischemia in rats.
    4. The results demonstrated that overexpression of TFPI gene might induce VSMC apoptosis in vitro through the mitochondrial pathway; meanwhile, IAP-1 expression is decreased.
      Title: Adenovirus-mediated gene transfer of tissue factor pathway inhibitor induces apoptosis in vascular smooth muscle cells.
    5. The expression of tissue factor and tissue factor pathway inhibitor in aortic smooth muscle cells is up-regulated in synthetic compared to contractile phenotype.
      Title: The expression of tissue factor and tissue factor pathway inhibitor in aortic smooth muscle cells is up-regulated in synthetic compared to contractile phenotype.
    6. TFPI expression is induced in cardiomyocytes, but not in endothelial cells, by IL-1beta.
      Title: Production of tissue factor pathway inhibitor in cardiomyocytes and its upregulation by interleukin-1.
    7. This is the first report showing that direct inhibition of TF-mediated coagulation activation abrogates bleomycin-induced pulmonary fibrosis.
      Title: Intratracheal gene transfer of tissue factor pathway inhibitor attenuates pulmonary fibrosis.
    8. Rapid atrial pacing acutely downregulated the gene expression of thrombomodulin and TFPI in rat atrial endocardium, thereby inducing local coagulation imbalance on the internal surface of the atrial cavity
      Title: Thrombomodulin and tissue factor pathway inhibitor in endocardium of rapidly paced rat atria.
    9. TFPI levels decreased significantly at 24 hours in burn, septic injury, and burn+septic injury groups, followed by incomplete rebound recovery at 72 hours
      Title: Tissue factor pathway inhibitor and thrombin activatable fibrinolytic inhibitor plasma levels following burn and septic injuries in rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to steroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tissue factor pathway inhibitor
    Names
    EPI
    LACI
    extrinsic pathway inhibitor
    lipoprotein-associated coagulation inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177321.1 → NP_001170792.1  tissue factor pathway inhibitor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001170792.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC087020
      UniProtKB/TrEMBL
      A0A8I5Y6C8, Q5PQU8
      Related
      ENSRNOP00000054493.2, ENSRNOT00000057685.5
      Conserved Domains (1) summary
      cd00109
      Location:122 → 174
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    2. NM_017200.1 → NP_058896.1  tissue factor pathway inhibitor isoform 1 precursor

      See identical proteins and their annotated locations for NP_058896.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      D10926
      UniProtKB/Swiss-Prot
      Q02445
      UniProtKB/TrEMBL
      A0A8L2Q2B4, A6HMQ1
      Conserved Domains (2) summary
      cd00109
      Location:122 → 174
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:221 → 272
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      89939862..89989253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761981.4 → XP_008760203.1  tissue factor pathway inhibitor isoform X1

      See identical proteins and their annotated locations for XP_008760203.1

      UniProtKB/TrEMBL
      A0A8L2Q2B4
      Conserved Domains (2) summary
      cd00109
      Location:122 → 174
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:225 → 276
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    2. XM_063283202.1 → XP_063139272.1  tissue factor pathway inhibitor isoform X2

      UniProtKB/Swiss-Prot
      Q02445
      UniProtKB/TrEMBL
      A0A8L2Q2B4, A6HMQ1

    3. XM_039104441.2 → XP_038960369.1  tissue factor pathway inhibitor isoform X2

      UniProtKB/Swiss-Prot
      Q02445
      UniProtKB/TrEMBL
      A0A8L2Q2B4, A6HMQ1
      Conserved Domains (2) summary
      cd00109
      Location:122 → 174
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:221 → 272
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    4. XM_063283203.1 → XP_063139273.1  tissue factor pathway inhibitor isoform X2

      UniProtKB/Swiss-Prot
      Q02445
      UniProtKB/TrEMBL
      A0A8L2Q2B4, A6HMQ1

    5. XM_008761982.2 → XP_008760204.1  tissue factor pathway inhibitor isoform X1

      See identical proteins and their annotated locations for XP_008760204.1

      UniProtKB/TrEMBL
      A0A8L2Q2B4
      Conserved Domains (2) summary
      cd00109
      Location:122 → 174
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:225 → 276
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    6. XM_008761980.4 → XP_008760202.1  tissue factor pathway inhibitor isoform X1

      See identical proteins and their annotated locations for XP_008760202.1

      UniProtKB/TrEMBL
      A0A8L2Q2B4
      Conserved Domains (2) summary
      cd00109
      Location:122 → 174
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:225 → 276
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    7. XM_006234440.5 → XP_006234502.1  tissue factor pathway inhibitor isoform X2

      See identical proteins and their annotated locations for XP_006234502.1

      UniProtKB/Swiss-Prot
      Q02445
      UniProtKB/TrEMBL
      A0A8L2Q2B4, A6HMQ1
      Related
      ENSRNOP00000078992.1
      Conserved Domains (2) summary
      cd00109
      Location:122 → 174
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:221 → 272
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    8. XM_006234441.4 → XP_006234503.1  tissue factor pathway inhibitor isoform X2

      See identical proteins and their annotated locations for XP_006234503.1

      UniProtKB/Swiss-Prot
      Q02445
      UniProtKB/TrEMBL
      A0A8L2Q2B4, A6HMQ1
      Conserved Domains (2) summary
      cd00109
      Location:122 → 174
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:221 → 272
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    9. XM_008761983.4 → XP_008760205.1  tissue factor pathway inhibitor isoform X1

      See identical proteins and their annotated locations for XP_008760205.1

      UniProtKB/TrEMBL
      A0A8L2Q2B4
      Conserved Domains (2) summary
      cd00109
      Location:122 → 174
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:225 → 276
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    10. XM_008761984.4 → XP_008760206.1  tissue factor pathway inhibitor isoform X1

      See identical proteins and their annotated locations for XP_008760206.1

      UniProtKB/TrEMBL
      A0A8L2Q2B4
      Conserved Domains (2) summary
      cd00109
      Location:122 → 174
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:225 → 276
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    11. XM_006234444.4 → XP_006234506.1  tissue factor pathway inhibitor isoform X2

      See identical proteins and their annotated locations for XP_006234506.1

      UniProtKB/Swiss-Prot
      Q02445
      UniProtKB/TrEMBL
      A0A8L2Q2B4, A6HMQ1
      Conserved Domains (2) summary
      cd00109
      Location:122 → 174
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:221 → 272
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    12. XM_063283204.1 → XP_063139274.1  tissue factor pathway inhibitor isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y6C8, Q5PQU8

    13. XM_063283208.1 → XP_063139278.1  tissue factor pathway inhibitor isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y6C8

    14. XM_063283206.1 → XP_063139276.1  tissue factor pathway inhibitor isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y6C8, Q5PQU8

    15. XM_063283210.1 → XP_063139280.1  tissue factor pathway inhibitor isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y6C8

    16. XM_039104442.2 → XP_038960370.1  tissue factor pathway inhibitor isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y6C8
      Conserved Domains (1) summary
      cd00109
      Location:122 → 174
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    17. XM_008761986.4 → XP_008760208.1  tissue factor pathway inhibitor isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y6C8
      Conserved Domains (1) summary
      cd00109
      Location:122 → 174
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    18. XM_008761985.3 → XP_008760207.1  tissue factor pathway inhibitor isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y6C8
      Conserved Domains (1) summary
      cd00109
      Location:122 → 174
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    19. XM_063283205.1 → XP_063139275.1  tissue factor pathway inhibitor isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y6C8, Q5PQU8

    20. XM_063283207.1 → XP_063139277.1  tissue factor pathway inhibitor isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y6C8, Q5PQU8

    21. XM_063283209.1 → XP_063139279.1  tissue factor pathway inhibitor isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y6C8

    22. XM_063283211.1 → XP_063139281.1  tissue factor pathway inhibitor isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y6C8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02445.1 GenPept UniProtKB/Swiss-Prot:Q02445

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