Gucy2f guanylate cyclase 2F [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gucy2fprovided by RGD
Official Full Name: guanylate cyclase 2Fprovided by RGD
Primary source: RGD:620439
See related: Ensembl:ENSRNOG00000019086 AllianceGenome:RGD:620439
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables guanylate cyclase activity and identical protein binding activity. Involved in cGMP-mediated signaling. Located in plasma membrane. Orthologous to human GUCY2F (guanylate cyclase 2F, retinal). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 3.2) and Brain (RPKM 0.2) See more
Orthologs: human mouse all
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Genomic context

Location:: Xq33

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (110507183..110605017, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (105710356..105808183, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (113372240..113474210, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Gucy2f (e-PCR), detects polymorphism
- UniSTS:525456

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of light stimulus involved in visual perception	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in rod photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
located_in rod photoreceptor outer segment	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: retinal guanylyl cyclase 2

Names: GC-F; RETGC-2; ROS-GC2; guanylate cyclase 2F, retinal; guanylate cyclase F; rod outer segment membrane guanylate cyclase 2

NP_446283.1

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053831.2 → NP_446283.1 retinal guanylyl cyclase 2 precursor

See identical proteins and their annotated locations for NP_446283.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

P51842

UniProtKB/TrEMBL

A6KG67

Related

ENSRNOP00000049500.2, ENSRNOT00000046804.3

Conserved Domains (7) summary

cd06371
Location:54 → 435

PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues

smart00219
Location:565 → 809

TyrKc; Tyrosine kinase, catalytic domain

smart00044
Location:848 → 1040

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:875 → 1062

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam01094
Location:75 → 412

ANF_receptor; Receptor family ligand binding region

pfam07701
Location:824 → 869

HNOBA; Heme NO binding associated

cl21453
Location:545 → 815

PKc_like; Protein Kinases, catalytic domain