Bmp5 bone morphogenetic protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bmp5provided by RGD
Official Full Name: bone morphogenetic protein 5provided by RGD
Primary source: RGD:1305979
See related: Ensembl:ENSRNOG00000010917 AllianceGenome:RGD:1305979
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable BMP receptor binding activity and cytokine activity. Predicted to be involved in several processes, including animal organ development; negative regulation of steroid hormone biosynthetic process; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within several processes, including anterior head development; ear development; and male genitalia development. Located in extracellular space and vesicle. Orthologous to human BMP5 (bone morphogenetic protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 42.9), Lung (RPKM 37.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (85397629..85520374)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (76517164..76639925)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (82669466..82950273)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that BMP5 is widely expressed throughout the adult CNS, and this abundant expression in the adult brain strongly supports the idea that BMP5 plays important roles not only in the developing brain but also in the adult brain
Title: BMP5 expression in the adult rat brain.
Bmp5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes cartilage matrix synthesis in primary chondrocyte cultures.
Title: BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures.
BMP5 might play a fully paracrine role in rodent ovarian folliculogenesis.
Title: Bone morphogenetic protein 5 expression in the rat ovary: biological effects on granulosa cell proliferation and steroidogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:496642 (e-PCR)
- UniSTS:496642

Bmp5 (e-PCR), detects polymorphism
- UniSTS:496642

26.MMHAP76FRA11.seq (e-PCR)
- UniSTS:123754

PMC56999P1 (e-PCR)
- UniSTS:273363

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BMP receptor binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in allantois development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior head development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in cardiac septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in chorio-allantoic fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ear development	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion formation	ISO Inferred from Sequence Orthology more info
involved_in heart trabecula morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hindbrain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male genitalia development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of aldosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cortisol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in neural fold elevation formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pattern specification process	ISO Inferred from Sequence Orthology more info
involved_in pericardium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in pharyngeal system development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in type B pancreatic cell development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bone morphogenetic protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108168.1 → NP_001101638.1 bone morphogenetic protein 5 precursor

See identical proteins and their annotated locations for NP_001101638.1

Status: PROVISIONAL

Source sequence(s)

CH473954

UniProtKB/TrEMBL

A6I1F0, D4A7P9

Related

ENSRNOP00000014846.5, ENSRNOT00000014846.6

Conserved Domains (2) summary

smart00204
Location:353 → 454

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:31 → 304

TGFb_propeptide; TGF-beta propeptide