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    Ncoa4 nuclear receptor coactivator 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 619385, updated on 17-Mar-2024

    Summary

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    Official Symbol
    Ncoa4provided by RGD
    Official Full Name
    nuclear receptor coactivator 4provided by RGD
    Primary source
    RGD:1563014
    See related
    Ensembl:ENSRNOG00000019768 Ensembl:ENSRNOG00000063221 AllianceGenome:RGD:1563014
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription coactivator activity. Involved in response to hormone. Predicted to be located in autolysosome. Orthologous to human NCOA4 (nuclear receptor coactivator 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 1656.7), Kidney (RPKM 587.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ncoa4 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (7395502..7415846)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (7389222..7409564)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (8302950..8323294)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene oxidoreductase NAD-binding domain containing 1 Neighboring gene transfer RNA valine (anticodon AAC) 12 Neighboring gene uncharacterized LOC134482455 Neighboring gene microseminoprotein, beta Neighboring gene poly (ADP-ribose) glycohydrolase like 1 Neighboring gene small nucleolar RNA SNORA74 Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene poly (ADP-ribose) glycohydrolase Neighboring gene uncharacterized LOC134482454

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Direct regulation of androgen receptor-associated protein 70 by thyroid hormone and its receptors. Tai PJ, et al. Endocrinology, 2007 Jul. PMID 17412801
    2. Evaluation of steroid receptors, coregulators, and molecules associated with uterine receptivity in secretory endometria from untreated women with polycystic ovary syndrome. Quezada S, et al. Fertil Steril, 2006 Apr. PMID 16580389
    3. Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. Hu YC, et al. J Biol Chem, 2004 Aug 6. PMID 15166229
    4. Heterogeneous expression and functions of androgen receptor co-factors in primary prostate cancer. Li P, et al. Am J Pathol, 2002 Oct. PMID 12368219, Free PMC Article
    5. Loss of androgen receptor associated protein 70 (ARA70) expression in a subset of HER2-positive breast cancers. Kollara A, et al. Breast Cancer Res Treat, 2001 Jun. PMID 11561770

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage.
      Title: m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72479

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein targeting to lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autolysosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor coactivator 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034007.1 → NP_001029179.1  nuclear receptor coactivator 4

      See identical proteins and their annotated locations for NP_001029179.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AI031008, AI112421, BC061839, CB806310, CV119475, CV795771
      UniProtKB/TrEMBL
      A0A8I6A3B1, A6KFW8, B1H215, F7FLG1
      Related
      ENSRNOP00000026803.4, ENSRNOT00000026803.6
      Conserved Domains (1) summary
      pfam12489
      Location:231 → 323
      ARA70; Nuclear coactivator

    2. NM_001034008.1 → NP_001029180.1  nuclear receptor coactivator 4

      See identical proteins and their annotated locations for NP_001029180.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AI031008, AI112421, BC061839, CB758330, CV119475, CV795771
      UniProtKB/TrEMBL
      A0A8I6A3B1, A6KFW8, B1H215, F7FLG1
      Conserved Domains (1) summary
      pfam12489
      Location:231 → 323
      ARA70; Nuclear coactivator

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      7395502..7415846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252660.5 → XP_006252722.1  nuclear receptor coactivator 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1Q3, A0A8I6A3B1
      Related
      ENSRNOP00000085575.1
      Conserved Domains (1) summary
      pfam12489
      Location:239 → 331
      ARA70; Nuclear coactivator
    Nucleotide Protein Strain
    Heading Accession and Version

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