Syce3 synaptonemal complex central element protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Syce3provided by MGI
Official Full Name: synaptonemal complex central element protein 3provided by MGI
Primary source: MGI:MGI:1922709
See related: Ensembl:ENSMUSG00000078938 AllianceGenome:MGI:1922709
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TSEG2; TSEG-2; 1700007E06Rik
Summary: Involved in reciprocal meiotic recombination; spermatogenesis; and synaptonemal complex assembly. Acts upstream of or within positive regulation of apoptotic process. Located in central element. Is expressed in embryo and testis. Orthologous to human SYCE3 (synaptonemal complex central element protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 52.2) See more
Orthologs: human all
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Genomic context

Location:: 15 E3; 15 44.87 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (89274377..89294706, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (89390174..89410503, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3.
Title: Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3.
SCRE interacts with synaptonemal complex protein 1 (SYCP1) and synaptonemal complex central element 3 (SYCE3); the function of SCRE is to reinforce the integrity of the central elements, thereby stabilizing the SC and ensuring meiotic cell cycle progression
Title: SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.
TSEG-2 may participate in the apoptosis of spermatogenic cells and the pathogenesis of cryptorchidism.
Title: Expression pattern of testis-specific expressed gene 2 in cryptorchidism model and its role in apoptosis of spermatogenic cells.
SYCE3 is required for male and female fertility.
Title: A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility.
A novel mouse testis specific gene TSEG-2 was successfully cloned, which could be down-regulated by cryptorchidism-inducible 17-beta estradiol. [TSEG-2]
Title: [Cloning and expression of a novel mouse testis gene TSEG-2].
Transcripts highly enriched in ovary; gene identified as candidate female fertility factor.
Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of ectopic germ cell programmed cell death	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of developmental process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of reproductive process	IDA Inferred from Direct Assay more info	PubMed
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptonemal complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in central element	IBA Inferred from Biological aspect of Ancestor more info
located_in central element	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: synaptonemal complex central element protein 3

Names: testis-specific expressed protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162880.1 → NP_001156352.1 synaptonemal complex central element protein 3

See identical proteins and their annotated locations for NP_001156352.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.

Source sequence(s)

BC048615

Consensus CDS

CCDS49703.1

UniProtKB/Swiss-Prot

B5KM66

UniProtKB/TrEMBL

E7D6R1

Related

ENSMUSP00000131766.2, ENSMUST00000167959.2

Conserved Domains (1) summary

pfam15191
Location:1 → 85

Synaptonemal_3; Synaptonemal complex central element protein 3
NM_001162882.1 → NP_001156354.1 synaptonemal complex central element protein 3

See identical proteins and their annotated locations for NP_001156354.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.

Source sequence(s)

AK029781, BC048615

Consensus CDS

CCDS49703.1

UniProtKB/Swiss-Prot

B5KM66

UniProtKB/TrEMBL

E7D6R1

Related

ENSMUSP00000104937.3, ENSMUST00000109314.9

Conserved Domains (1) summary

pfam15191
Location:1 → 85

Synaptonemal_3; Synaptonemal complex central element protein 3