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    Cnot8 CCR4-NOT transcription complex, subunit 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363603, updated on 2-May-2024

    Summary

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    Official Symbol
    Cnot8provided by RGD
    Official Full Name
    CCR4-NOT transcription complex, subunit 8provided by RGD
    Primary source
    RGD:1306401
    See related
    Ensembl:ENSRNOG00000002630 AllianceGenome:RGD:1306401
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable poly(A)-specific ribonuclease activity. Predicted to be involved in exonucleolytic catabolism of deadenylated mRNA and positive regulation of cell population proliferation. Predicted to be located in nucleus. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Orthologous to human CNOT8 (CCR4-NOT transcription complex subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 312.9), Spleen (RPKM 240.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cnot8 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (42782042..42795207)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (42281614..42294740)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (43538150..43551271)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene fatty acid hydroxylase domain containing 2 Neighboring gene uncharacterized LOC134480692 Neighboring gene transfer RNA serine (anticodon AGA) 43 Neighboring gene gem (nuclear organelle) associated protein 5 Neighboring gene mitochondrial ribosomal protein L22 Neighboring gene interferon gamma induced GTPase like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation. Aslam A, et al. Mol Biol Cell, 2009 Sep. PMID 19605561, Free PMC Article
    2. Conservation of the deadenylase activity of proteins of the Caf1 family in human. Bianchin C, et al. RNA, 2005 Apr. PMID 15769875, Free PMC Article
    3. CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells. Piao X, et al. Mol Cell Biol, 2010 Mar. PMID 20065043, Free PMC Article
    4. Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. Bogdan JA, et al. Biochem J, 1998 Dec 1. PMID 9820826, Free PMC Article
    5. The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Petit AP, et al. Nucleic Acids Res, 2012 Nov. PMID 22977175, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94581

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in miRNA-mediated gene silencing by mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 8
    NP_001008383.1
    XP_006246454.1
    XP_038942393.1
    XP_063125577.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008382.1 → NP_001008383.1  CCR4-NOT transcription complex subunit 8

      See identical proteins and their annotated locations for NP_001008383.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085856
      UniProtKB/TrEMBL
      A6HEQ7, F7F1V4, Q5U2U9
      Related
      ENSRNOP00000003555.3, ENSRNOT00000003555.5
      Conserved Domains (1) summary
      cl23804
      Location:1 → 263
      CAF1; CAF1 family ribonuclease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      42782042..42795207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086465.2 → XP_038942393.1  CCR4-NOT transcription complex subunit 8 isoform X1

      UniProtKB/TrEMBL
      A6HEQ7, F7F1V4, Q5U2U9
      Conserved Domains (1) summary
      cl23804
      Location:1 → 263
      CAF1; CAF1 family ribonuclease

    2. XM_006246392.5 → XP_006246454.1  CCR4-NOT transcription complex subunit 8 isoform X1

      See identical proteins and their annotated locations for XP_006246454.1

      UniProtKB/TrEMBL
      A6HEQ7, F7F1V4, Q5U2U9
      Conserved Domains (1) summary
      cl23804
      Location:1 → 263
      CAF1; CAF1 family ribonuclease

    3. XM_063269507.1 → XP_063125577.1  CCR4-NOT transcription complex subunit 8 isoform X1

      UniProtKB/TrEMBL
      A6HEQ7, F7F1V4, Q5U2U9
    Nucleotide Protein Strain
    Heading Accession and Version

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