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    Mfap3 microfibril associated protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287299, updated on 2-May-2024

    Summary

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    Official Symbol
    Mfap3provided by RGD
    Official Full Name
    microfibril associated protein 3provided by RGD
    Primary source
    RGD:1359463
    See related
    Ensembl:ENSRNOG00000002443 AllianceGenome:RGD:1359463
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be integral component of membrane. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Orthologous to human MFAP3 (microfibril associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 101.1), Kidney (RPKM 92.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mfap3 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (42197292..42213011)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (41696788..41711490)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (42933077..42945591)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553349 Neighboring gene uncharacterized LOC120095106 Neighboring gene glutamate ionotropic receptor AMPA type subunit 1 Neighboring gene family with sequence similarity 114, member A2 Neighboring gene uncharacterized LOC134480689 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 10 Neighboring gene SAP30-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of the microfibrillar protein MFAP3 and assignment of the gene to human chromosome 5q32-q33.2. Abrams WR, et al. Genomics, 1995 Mar 1. PMID 7782085
    2. Functional identification of neuroprotective molecules. Dai C, et al. PLoS One, 2010 Nov 24. PMID 21124846, Free PMC Article
    3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94011

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    microfibril-associated glycoprotein 3
    Names
    microfibrillar-associated protein 3
    neuroprotective protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007609.1 → NP_001007610.1  microfibril-associated glycoprotein 3 precursor

      See identical proteins and their annotated locations for NP_001007610.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079064
      UniProtKB/Swiss-Prot
      Q6AYF7
      UniProtKB/TrEMBL
      A6HEP5, B3SVE7
      Related
      ENSRNOP00000003361.3, ENSRNOT00000003361.4
      Conserved Domains (2) summary
      smart00408
      Location:60 → 122
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:62 → 72
      Ig; Ig strand B [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      42197292..42213011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246379.4 → XP_006246441.1  microfibril-associated glycoprotein 3 isoform X1

      See identical proteins and their annotated locations for XP_006246441.1

      UniProtKB/Swiss-Prot
      Q6AYF7
      UniProtKB/TrEMBL
      A6HEP5, B3SVE7
      Conserved Domains (2) summary
      smart00408
      Location:60 → 122
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:62 → 72
      Ig; Ig strand B [structural motif]

    2. XM_039085387.2 → XP_038941315.1  microfibril-associated glycoprotein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6AYF7
      UniProtKB/TrEMBL
      A6HEP5, B3SVE7
      Conserved Domains (2) summary
      smart00408
      Location:60 → 122
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:62 → 72
      Ig; Ig strand B [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYF7.1 GenPept UniProtKB/Swiss-Prot:Q6AYF7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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