Rab33a RAB33A, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab33aprovided by RGD
Official Full Name: RAB33A, member RAS oncogene familyprovided by RGD
Primary source: RGD:1563280
See related: Ensembl:ENSRNOG00000006698 AllianceGenome:RGD:1563280
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563280
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in antigen processing and presentation. Predicted to be active in Golgi apparatus and endosome. Orthologous to human RAB33A (RAB33A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 250.3), Brain (RPKM 89.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq36

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (132572133..132584255)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (127694219..127706378)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (135348799..135360204)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicated that Rab33A is a novel component of IPR-stimulated amylase secretion from parotid acinar cells
Title: The small GTPase Rab33A participates in regulation of amylase release from parotid acinar cells.
Atg16L1 regulates not only autophagy in all cell types, but also secretion from dense-core vesicles, presumably by acting as a Rab33A effector, in particular cell types.
Title: Atg16L1, an essential factor for canonical autophagy, participates in hormone secretion from PC12 cells independently of autophagic activity.
These data suggest that Rab33a participates in axon outgrowth by mediating anterograde axonal transport of synaptophysin-positive vesicles and their concomitant fusion at the growth cones
Title: Rab33a mediates anterograde vesicular transport for membrane exocytosis and axon outgrowth.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related protein Rab-33A

Names: RAB33A, member of RAS oncogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108257.1 → NP_001101727.1 ras-related protein Rab-33A

See identical proteins and their annotated locations for NP_001101727.1

Status: PROVISIONAL

Source sequence(s)

CH473991

UniProtKB/TrEMBL

A6JMQ7, D3ZCU8

Related

ENSRNOP00000008868.2, ENSRNOT00000008868.5

Conserved Domains (2) summary

cd04115
Location:35 → 204

Rab33B_Rab33A; Rab GTPase family 33 includes Rab33A and Rab33B

smart00175
Location:37 → 205

RAB; Rab subfamily of small GTPases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

132572133..132584255

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099851.2 → XP_038955779.1 ras-related protein Rab-33A isoform X1

Conserved Domains (1) summary

cl38936
Location:35 → 94

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases