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    Arhgef26 Rho guanine nucleotide exchange factor 26 [ Mus musculus (house mouse) ]

    Gene ID: 622434, updated on 9-May-2024

    Summary

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    Official Symbol
    Arhgef26provided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor 26provided by MGI
    Primary source
    MGI:MGI:1918053
    See related
    Ensembl:ENSMUSG00000036885 AllianceGenome:MGI:1918053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SGEF; 4631416L12Rik; 8430436L14Rik
    Summary
    Acts upstream of or within endothelial cell morphogenesis and ruffle assembly. Is expressed in pons ventricular layer. Orthologous to human ARHGEF26 (Rho guanine nucleotide exchange factor 26). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 12.9), cerebellum adult (RPKM 6.2) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgef26 in Genome Data Viewer
    Location:
    3 E1; 3 29.97 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (62244946..62369642)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (62338777..62462221)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 1 (chaperonin) pseudogene 16 Neighboring gene STARR-seq mESC enhancer starr_07808 Neighboring gene STARR-seq mESC enhancer starr_07809 Neighboring gene STARR-seq mESC enhancer starr_07810 Neighboring gene STARR-seq mESC enhancer starr_07811 Neighboring gene STARR-seq mESC enhancer starr_07812 Neighboring gene predicted gene, 57711 Neighboring gene predicted gene, 33923 Neighboring gene STARR-seq mESC enhancer starr_07813 Neighboring gene STARR-seq mESC enhancer starr_07814 Neighboring gene DEAH-box helicase 36 Neighboring gene STARR-seq mESC enhancer starr_07815 Neighboring gene STARR-seq mESC enhancer starr_07816 Neighboring gene G protein-coupled receptor 149 Neighboring gene STARR-seq mESC enhancer starr_07817

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling. Zhu QM, et al. Cardiovasc Res, 2022 Oct 21. PMID 34849650, Free PMC Article
    2. The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis. Samson T, et al. PLoS One, 2013. PMID 23372835, Free PMC Article
    3. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
    4. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis.
      Title: The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endothelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ruffle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 26
    Names
    Rho guanine nucleotide exchange factor (GEF) 26
    Src homology 3 domain-containing guanine nucleotide exchange factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081295.1 → NP_001074764.1  rho guanine nucleotide exchange factor 26

      See identical proteins and their annotated locations for NP_001074764.1

      Status: VALIDATED

      Source sequence(s)
      AC114424, AC122883
      Consensus CDS
      CCDS38443.1
      UniProtKB/TrEMBL
      D3YYY8
      Related
      ENSMUSP00000078281.7, ENSMUST00000079300.13
      Conserved Domains (3) summary
      cd11938
      Location:791 → 845
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:641 → 779
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:441 → 620
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      62244946..62369642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163208.1 → XP_036019101.1  rho guanine nucleotide exchange factor 26 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:18 → 239
      PHA03247; large tegument protein UL36; Provisional
      cl02571
      Location:441 → 493
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    Nucleotide Protein Strain
    Heading Accession and Version

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