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    Dmkn dermokine [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361548, updated on 3-Apr-2024

    Summary

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    Symbol
    Dmknprovided by RGD
    Full Name
    dermokineprovided by RGD
    Primary source
    RGD:1561521
    See related
    Ensembl:ENSRNOG00000055934 AllianceGenome:RGD:1561521
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561521
    Summary
    Predicted to act upstream of or within cornified envelope assembly. Predicted to be located in extracellular space. Orthologous to human DMKN (dermokine). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 58.2), Brain (RPKM 5.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dmkn in Genome Data Viewer
    Location:
    1q21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95140737..95158676)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86013237..86031243)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89215266..89229696)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 147 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Neighboring gene suprabasin Neighboring gene keratinocyte differentiation associated protein Neighboring gene ribosomal protein L36 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mice deficient for the epidermal dermokine β and γ isoforms display transient cornification defects. Leclerc EA, et al. J Cell Sci, 2014 Jul 1. PMID 24794495
    2. Identification of a conserved cluster of skin-specific genes encoding secreted proteins. Moffatt P, et al. Gene, 2004 Jun 9. PMID 15256262
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cornified envelope assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dermokine

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173357.1 → NP_001166828.1  dermokine precursor

      See identical proteins and their annotated locations for NP_001166828.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166816
      UniProtKB/TrEMBL
      A0A1W2Q687, A6JA22, B2RYK9
      Related
      ENSRNOP00000076175.2, ENSRNOT00000093612.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      95140737..95158676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266496.1 → XP_063122566.1  dermokine isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q687, B2RYK9

    2. XM_063266497.1 → XP_063122567.1  dermokine isoform X2

      UniProtKB/TrEMBL
      A0A0G2K3X0

    3. XM_039081975.2 → XP_038937903.1  dermokine isoform X2

      UniProtKB/TrEMBL
      A0A0G2K3X0, A6JA22
      Related
      ENSRNOP00000072810.2
      Conserved Domains (1) summary
      cd21118
      Location:19 → 500
      dermokine

    4. XM_063266498.1 → XP_063122568.1  dermokine isoform X3

      UniProtKB/TrEMBL
      A6JA23

    5. XM_039081986.2 → XP_038937914.1  dermokine isoform X3

      UniProtKB/TrEMBL
      A6JA23
      Conserved Domains (1) summary
      cl11081
      Location:26 → 104
      dermokine
    Nucleotide Protein Strain
    Heading Accession and Version

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