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    Calr3 calreticulin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364529, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Calr3provided by RGD
    Official Full Name
    calreticulin 3provided by RGD
    Primary source
    RGD:1309243
    See related
    Ensembl:ENSRNOG00000013260 AllianceGenome:RGD:1309243
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein folding chaperone. Predicted to be involved in protein folding and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum lumen and nuclear envelope. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human CALR3 (calreticulin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 367.3), Kidney (RPKM 35.7) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Calr3 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (17430105..17456777)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17396064..17423166)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19097391..19124062)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member E1 Neighboring gene similar to human chromosome 19 open reading frame 44 Neighboring gene calcium homeostasis endoplasmic reticulum protein Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene KLF transcription factor 2 Neighboring gene adaptor related protein complex 1 subunit mu 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Calreticulin-2 is localized in the lumen of the endoplasmic reticulum but is not a Ca2+ -binding protein. Nomura R, et al. Histochem Cell Biol, 2011 Jun. PMID 21590275
    2. Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected]. Tokuhiro K, et al. Proc Natl Acad Sci U S A, 2012 Mar 6. PMID 22357757, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calreticulin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012212.1 → NP_001012212.1  calreticulin-3 precursor

      See identical proteins and their annotated locations for NP_001012212.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079049
      UniProtKB/TrEMBL
      F7EM31, Q6AYG8
      Related
      ENSRNOP00000018018.4, ENSRNOT00000018018.6
      Conserved Domains (1) summary
      pfam00262
      Location:23 → 315
      Calreticulin; Calreticulin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      17430105..17456777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094712.2 → XP_038950640.1  calreticulin-3 isoform X1

      Conserved Domains (1) summary
      pfam00262
      Location:23 → 257
      Calreticulin; Calreticulin family
    Nucleotide Protein Strain
    Heading Accession and Version

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