Rbm12 RNA binding motif protein 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbm12provided by RGD
Official Full Name: RNA binding motif protein 12provided by RGD
Primary source: RGD:1594333
See related: Ensembl:ENSRNOG00000019723 AllianceGenome:RGD:1594333
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in schizophrenia 19. Orthologous to several human genes including CPNE1 (copine 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 168.5), Spleen (RPKM 115.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (165069744..165089994, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (144609661..144629911, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (151616038..151658427, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

REN58605 (e-PCR)
- UniSTS:383405

REN58606 (e-PCR)
- UniSTS:383406

REN58611 (e-PCR)
- UniSTS:383411

ECD04598 (e-PCR)
- UniSTS:285670

UniSTS:479221 (e-PCR)
- UniSTS:479221

Rbm12 (e-PCR), detects polymorphism
- UniSTS:479221

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NF-kappaB binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in neuron projection extension	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA-binding protein 12

Names: swan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037657.2 → NP_001032746.1 RNA-binding protein 12

See identical proteins and their annotated locations for NP_001032746.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A9K3Y8G9, D4A116, Q6XLI7

Conserved Domains (7) summary

PHA03377
Location:642 → 701

PHA03377; EBNA-3C; Provisional

PRK15313
Location:770 → 822

PRK15313; intestinal colonization autotransporter adhesin MisL

cd12745
Location:1 → 92

RRM1_RBM12; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12 (RBM12) and similar proteins

cd12512
Location:421 → 521

RRM3_RBM12; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12 (RBM12) and similar proteins

cd12747
Location:303 → 377

RRM2_RBM12; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12 (RBM12) and similar proteins

cd12749
Location:545 → 632

RRM4_RBM12; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12 (RBM12) and similar proteins

cd12751
Location:955 → 1030

RRM5_RBM12; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12 (RBM12) and similar proteins
NM_001409091.1 → NP_001396020.1 RNA-binding protein 12

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A9K3Y8G9, D4A116, Q6XLI7

Related

ENSRNOP00000043185.2, ENSRNOT00000047246.3