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    Fgf14 fibroblast growth factor 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63851, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Fgf14provided by RGD
    Official Full Name
    fibroblast growth factor 14provided by RGD
    Primary source
    RGD:620165
    See related
    Ensembl:ENSRNOG00000009288 AllianceGenome:RGD:620165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fhf4; FGF-14
    Summary
    Enables growth factor activity. Acts upstream of or within several processes, including positive regulation of high voltage-gated calcium channel activity; regulation of postsynaptic membrane potential; and regulation of synaptic vesicle recycling. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 27. Orthologous to human FGF14 (fibroblast growth factor 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 168.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fgf14 in Genome Data Viewer
    Location:
    15q25
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (107442800..108086486, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (101045033..101679888, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (110382274..111077027, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene U6atac minor spliceosomal RNA Neighboring gene integrin subunit beta like 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Ssu72 RNA polymerase II CTD phosphatase, pseudogene 1 Neighboring gene transfer RNA proline (anticodon AGG) 91 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC120097183 Neighboring gene olfactory receptor pseudogene 1647 Neighboring gene pyruvate kinase M1/2, pseudogene 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural analysis of a mature hst-1 protein with transforming growth factor activity. Miyagawa K, et al. Biochem Biophys Res Commun, 1991 Jan 15. PMID 1824921
    2. FGF14 regulates presynaptic Ca2+ channels and synaptic transmission. Yan H, et al. Cell Rep, 2013 Jul 11. PMID 23831029, Free PMC Article
    3. Structure and expression of a novel isoform of mouse FGF homologous factor (FHF)-4. Yamamoto S, et al. Biochim Biophys Acta, 1998 May 29. PMID 9602045
    4. Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells. Martinez-Espinosa PL, et al. J Gen Physiol, 2021 Apr 5. PMID 33651884, Free PMC Article
    5. Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Goldfarb M, et al. Neuron, 2007 Aug 2. PMID 17678857, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells.
      Title: Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells.
    2. identified the PI3K/Akt pathway, the cell-cycle regulator Wee1 kinase, and protein kinase C (PKC) as prospective regulatory nodes of neuronal excitability through modulation of the FGF14:Nav1.6 complex.
      Title: Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation.
    3. FGF14 regulates presynaptic Ca2+ channels in granule cell and EPSCs in Purkinje cells.
      Title: FGF14 regulates presynaptic Ca2+ channels and synaptic transmission.
    4. inhibition of GSK3 reduces the assembly of the FGF14.Nav channel complex, modifies FGF14-dependent regulation of Na(+) currents, and induces dissociation and subcellular redistribution of the native FGF14.Nav channel complex in hippocampal neurons.
      Title: The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of postsynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of synaptic vesicle recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    fibroblast growth factor 14
    Names
    FGF homologus factor 4b
    fibroblast growth factor homologous factor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411965.1 → NP_001398894.1  fibroblast growth factor 14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6A9Y8, A6HUN2, Q794I6
      Related
      ENSRNOP00000088042.1, ENSRNOT00000102677.1

    2. NM_022223.3 → NP_071559.2  fibroblast growth factor 14 isoform 1

      See identical proteins and their annotated locations for NP_071559.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q8R5L7
      UniProtKB/TrEMBL
      A6HUN3
      Related
      ENSRNOP00000042838.5, ENSRNOT00000041551.6
      Conserved Domains (1) summary
      pfam00167
      Location:72 → 197
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      107442800..108086486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093636.2 → XP_038949564.1  fibroblast growth factor 14 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9Y8, A6HUN2, Q794I6
      Conserved Domains (1) summary
      pfam00167
      Location:77 → 202
      FGF; Fibroblast growth factor

    2. XM_063274614.1 → XP_063130684.1  fibroblast growth factor 14 isoform X2

      UniProtKB/TrEMBL
      Q8R4X0

    3. XM_039093639.2 → XP_038949567.1  fibroblast growth factor 14 isoform X2

      UniProtKB/TrEMBL
      Q8R4X0
      Conserved Domains (1) summary
      pfam00167
      Location:1 → 113
      FGF; Fibroblast growth factor

    4. XM_063274613.1 → XP_063130683.1  fibroblast growth factor 14 isoform X2

      UniProtKB/TrEMBL
      Q8R4X0

    5. XM_063274611.1 → XP_063130681.1  fibroblast growth factor 14 isoform X2

      UniProtKB/TrEMBL
      Q8R4X0

    6. XM_063274612.1 → XP_063130682.1  fibroblast growth factor 14 isoform X2

      UniProtKB/TrEMBL
      Q8R4X0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R5L7.1 GenPept UniProtKB/Swiss-Prot:Q8R5L7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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