Atp4a ATPase H+/K+ transporting subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp4aprovided by RGD
Official Full Name: ATPase H+/K+ transporting subunit alphaprovided by RGD
Primary source: RGD:2177
See related: Ensembl:ENSRNOG00000020985 AllianceGenome:RGD:2177
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hka; Hkatpc
Summary: Predicted to enable P-type potassium transmembrane transporter activity and metal ion binding activity. Predicted to be involved in cellular monovalent inorganic cation homeostasis and inorganic cation transmembrane transport. Predicted to act upstream of or within pH reduction; regulation of proton transport; and response to xenobiotic stimulus. Located in apical plasma membrane. Orthologous to human ATP4A (ATPase H+/K+ transporting subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 3.4), Thymus (RPKM 1.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (95089122..95102277)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (85961607..85974972)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (89162700..89175504)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type potassium:proton transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type potassium:proton transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type potassium:proton transporter activity	ISO Inferred from Sequence Orthology more info
enables P-type potassium:proton transporter activity	TAS Traceable Author Statement more info	PubMed
enables P-type sodium:potassium-exchanging transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables potassium ion binding	ISO Inferred from Sequence Orthology more info
enables potassium ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in establishment or maintenance of transmembrane electrochemical gradient	IEA Inferred from Electronic Annotation more info
involved_in gastric acid secretion	TAS Traceable Author Statement more info	PubMed
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in pH reduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pH reduction	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of proton transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of proton transport	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of potassium:proton exchanging ATPase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium-transporting ATPase alpha chain 1

Names: ATPase H+/K+ transporting alpha subunit; ATPase, H+/K+ exchanging, alpha polypeptide; ATPase, H+/K+ transporting, alpha polypeptide; H+,K+-ATPase alpha subunit; gastric H(+)/K(+) ATPase subunit alpha; gastric H,K-ATPase catalytic subunit; hydrogen/potassium-exchanging ATPase 4A; proton pump

NP_036641.1

EC 7.2.2.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012509.2 → NP_036641.1 potassium-transporting ATPase alpha chain 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6JA10, F1LRK1

Related

ENSRNOP00000028508.5, ENSRNOT00000028508.8

Conserved Domains (7) summary

smart00831
Location:50 → 124

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:687 → 742

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:42 → 1034

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:145 → 375

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:809 → 1018

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam09040
Location:2 → 27

H-K_ATPase_N; Gastric H+/K+-ATPase, N terminal domain

pfam13246
Location:437 → 531

Cation_ATPase; Cation transport ATPase (P-type)