Usf2 upstream transcription factor 2, c-fos interacting [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Usf2provided by RGD
Official Full Name: upstream transcription factor 2, c-fos interactingprovided by RGD
Primary source: RGD:620975
See related: Ensembl:ENSRNOG00000053725 AllianceGenome:RGD:620975
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human USF2 (upstream transcription factor 2, c-fos interacting). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 183.2), Heart (RPKM 157.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (95302109..95321334, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (86174703..86185942, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (89371798..89383005, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upstream stimulatory factors (USF1 and USF2) induce Nr5a1 and Shbg gene expression during the onset of rat Sertoli cell differentiation.
Title: Upstream stimulatory factor induces Nr5a1 and Shbg gene expression during the onset of rat Sertoli cell differentiation.
Data suggest that glycated albumin upregulated USF2 gene transcription in mesangial cells through NF-kappaB-dependent transactivation of the USF2 promoter.
Title: Glycated albumin upregulates upstream stimulatory factor 2 gene transcription in mesangial cells.
USF has a role in increasing TGF-beta1 protein levels, but not in indusing G1 phase arrest
Title: Overexpression of USF increases TGF-beta1 protein levels, but G1 phase arrest was not induced in FRTL-5 cells.
high glucose levels up-regulate USF2 gene transcription in mesangial cells through CREB-dependent transactivation of the USF2 promoter.
Title: High glucose levels upregulate upstream stimulatory factor 2 gene transcription in mesangial cells.
USF1 and USF2 are important contributors to neuronal-specific and mitogen-activated protein kinase regulation of the CGRP gene in trigeminal ganglion neurons
Title: Control of the calcitonin gene-related peptide enhancer by upstream stimulatory factor in trigeminal ganglion neurons.
USF1 and 2 transactivate rat and human PF4 promoters and may play an important role in megakaryocytic gene expression
Title: Upstream stimulatory factors stimulate transcription through E-box motifs in the PF4 gene in megakaryocytes.
USF2 has a role in upregulating thrombospondin 1 gene transcription and TGF-beta activity through antagonism of cGMP-dependent protein kinase repression
Title: Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-beta activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2.

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General gene information

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Markers

U01663 (e-PCR)
- UniSTS:125639

BF406210 (e-PCR)
- UniSTS:248312

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables bHLH transcription factor binding	IEA Inferred from Electronic Annotation more info
enables bHLH transcription factor binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lactation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lactation	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: upstream stimulatory factor 2

Names: major late transcription factor 2; transcription factor USF2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031139.1 → NP_112401.1 upstream stimulatory factor 2

See identical proteins and their annotated locations for NP_112401.1

Status: PROVISIONAL

Source sequence(s)

AB047556

UniProtKB/Swiss-Prot

Q63665, Q76MJ1, Q76MU2, Q9EQX1, Q9EQX2, Q9EQX3

UniProtKB/TrEMBL

A2VCW7

Related

ENSRNOP00000072660.2, ENSRNOT00000087381.2

Conserved Domains (2) summary

cd18923
Location:229 → 308

bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins

pfam06005
Location:290 → 334

ZapB; Cell division protein ZapB

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

95302109..95321334 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092335.2 → XP_038948263.1 upstream stimulatory factor 2 isoform X1

UniProtKB/TrEMBL

A2VCW7

Related

ENSRNOP00000094253.1

Conserved Domains (2) summary

pfam06005
Location:223 → 267

ZapB; Cell division protein ZapB

cl00081
Location:162 → 241

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily