Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnajb14provided by RGD
Official Full Name: DnaJ heat shock protein family (Hsp40) member B14provided by RGD
Primary source: RGD:1591949
See related: Ensembl:ENSRNOG00000060107 AllianceGenome:RGD:1591949
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Hsp70 protein binding activity. Predicted to be involved in several processes, including cellular response to misfolded protein; chaperone cofactor-dependent protein refolding; and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human DNAJB14 (DnaJ heat shock protein family (Hsp40) member B14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 121.7), Brain (RPKM 118.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (229032415..229075905)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (226358988..226409461)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (243108443..243151933)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU027298 (e-PCR)
- UniSTS:113443

MARC_31601-31602:1045759847:1 (e-PCR)
- UniSTS:269206

RH130397 (e-PCR)
- UniSTS:213681

ksks443 (e-PCR)
- UniSTS:514501

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to misfolded protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone cofactor-dependent protein refolding	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dnaJ homolog subfamily B member 14

Names: DnaJ (Hsp40) homolog, subfamily B, member 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109193.2 → NP_001102663.2 dnaJ homolog subfamily B member 14

See identical proteins and their annotated locations for NP_001102663.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A0G2JTM9, A6HW09, A6HW11

Related

ENSRNOP00000068773.1, ENSRNOT00000081989.2

Conserved Domains (3) summary

COG0484
Location:107 → 214

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

pfam00226
Location:108 → 169

DnaJ; DnaJ domain

pfam09320
Location:271 → 369

DUF1977; Domain of unknown function (DUF1977)