Plpp1 phospholipid phosphatase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plpp1provided by RGD
Official Full Name: phospholipid phosphatase 1provided by RGD
Primary source: RGD:621832
See related: Ensembl:ENSRNOG00000009980 AllianceGenome:RGD:621832
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ppap2a
Summary: Enables diacylglycerol diphosphate phosphatase activity; lipid phosphatase activity; and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation; phospholipid metabolic process; and sphingolipid metabolic process. Is integral component of plasma membrane. Orthologous to human PLPP1 (phospholipid phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 422.8), Kidney (RPKM 267.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (46172202..46233632)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (44439002..44500430)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (44664076..44726820)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH127716 (e-PCR)
- UniSTS:211026

D2Got27 (e-PCR)
- UniSTS:112081

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ceramide-1-phosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ceramide-1-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables ceramide-1-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables ceramide-1-phosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables diacylglycerol diphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables diacylglycerol diphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables lipid phosphatase activity	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidate phosphatase activity	TAS Traceable Author Statement more info	PubMed
enables sphingosine-1-phosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables sphingosine-1-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables sphingosine-1-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ceramide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ceramide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ceramide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in phospholipid dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in sphingosine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in sphingosine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingosine metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phospholipid phosphatase 1

Names: PAP-2a; PAP2-alpha; PAP2a; lipid phosphate phosphohydrolase 1; phosphatidate phosphohydrolase type 2a; phosphatidic acid phosphatase 2a; phosphatidic acid phosphatase type 2A

NP_071983.2

EC 3.1.3.106

EC 3.1.3.4

EC 3.6.1.75

XP_006232011.1

EC 3.1.3.106

EC 3.1.3.4

EC 3.6.1.75

XP_038958987.1

EC 3.1.3.106

EC 3.1.3.4

EC 3.6.1.75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022538.2 → NP_071983.2 phospholipid phosphatase 1

See identical proteins and their annotated locations for NP_071983.2

Status: PROVISIONAL

Source sequence(s)

BC061815

UniProtKB/Swiss-Prot

O08564, Q8K594

UniProtKB/TrEMBL

A0A8I5ZMN4, A6I5Q0, Q6P766

Related

ENSRNOP00000079410.1, ENSRNOT00000100018.1

Conserved Domains (1) summary

cd03384
Location:98 → 243

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

46172202..46233632

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231949.5 → XP_006232011.1 phospholipid phosphatase 1 isoform X1

See identical proteins and their annotated locations for XP_006232011.1

UniProtKB/TrEMBL

A0A8I5ZS66, A6I5P9, G3V9Y2

Related

ENSRNOP00000062843.3

Conserved Domains (1) summary

cd03384
Location:99 → 244

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
XM_039103059.2 → XP_038958987.1 phospholipid phosphatase 1 isoform X2

UniProtKB/TrEMBL

A6I5Q1

Conserved Domains (1) summary

cd03384
Location:28 → 173

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...