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    Fkbp1b FKBP prolyl isomerase 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58950, updated on 2-May-2024

    Summary

    Official Symbol
    Fkbp1bprovided by RGD
    Official Full Name
    FKBP prolyl isomerase 1Bprovided by RGD
    Primary source
    RGD:61835
    See related
    Ensembl:ENSRNOG00000047143 AllianceGenome:RGD:61835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    FKBP-1B; FKBP-12.6
    Summary
    Enables FK506 binding activity and cyclic nucleotide binding activity. Involved in several processes, including positive regulation of axon regeneration; response to hydrogen peroxide; and response to vitamin E. Located in intracellular membrane-bounded organelle. Biomarker of cardiomyopathy and congestive heart failure. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to human FKBP1B (FKBP prolyl isomerase 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 130.6), Kidney (RPKM 46.2) and 3 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fkbp1b in Genome Data Viewer
    Location:
    6q14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (33551583..33570055, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (27832128..27850600, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (29975863..29987252)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene profilin family, member 4 Neighboring gene tumor protein p53 inducible protein 3 Neighboring gene splicing factor 3B, subunit 6 Neighboring gene U6 spliceosomal RNA Neighboring gene WD repeat and coiled coil containing Neighboring gene MFSD2 lysolipid transporter B, sphingolipid

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FK506 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables FK506 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclic nucleotide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuronal action potential propagation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of axon regeneration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sequestering of calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein peptidyl-prolyl isomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to redox state ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to vitamin E IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    part_of calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in sarcoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP1B
    Names
    12.6 kDa FK506-binding protein
    12.6 kDa FKBP
    FK506-binding protein 1B
    PPIase FKBP1B
    calstabin-2
    immunophilin FKBP12.6
    rotamase
    NP_001388191.1
    NP_001388192.1
    NP_073166.1
    XP_017449825.1
    XP_038968726.1
    XP_038968727.1
    XP_038968728.1
    XP_038968730.1
    XP_038968731.1
    XP_038968733.1
    XP_038968734.1
    XP_063118449.1
    XP_063118450.1
    XP_063118451.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401262.1NP_001388191.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      Conserved Domains (1) summary
      pfam00254
      Location:689
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    2. NM_001401263.1NP_001388192.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
    3. NM_022675.2NP_073166.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform 1

      See identical proteins and their annotated locations for NP_073166.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P97534
      UniProtKB/TrEMBL
      A6HAJ4
      Related
      ENSRNOP00000067023.1, ENSRNOT00000071784.3
      Conserved Domains (1) summary
      pfam00254
      Location:13105
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      33551583..33570055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112806.2XP_038968734.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X9

      Conserved Domains (1) summary
      pfam00254
      Location:647
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    2. XM_039112798.2XP_038968726.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X1

    3. XM_039112803.2XP_038968731.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X5

      Conserved Domains (1) summary
      pfam00254
      Location:1391
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    4. XM_039112802.2XP_038968730.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X4

      Conserved Domains (1) summary
      pfam00254
      Location:1363
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    5. XM_017594336.3XP_017449825.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X8

      Conserved Domains (1) summary
      pfam00254
      Location:176
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    6. XM_063262381.1XP_063118451.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X8

    7. XM_039112800.2XP_038968728.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X3

      Conserved Domains (1) summary
      pfam00254
      Location:668
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    8. XM_039112805.2XP_038968733.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X7

      Related
      ENSRNOP00000092320.1
      Conserved Domains (1) summary
      pfam00254
      Location:1363
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    9. XM_063262380.1XP_063118450.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X6

    10. XM_063262379.1XP_063118449.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X6

    11. XM_039112799.2XP_038968727.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X2

      Conserved Domains (1) summary
      pfam00254
      Location:1384
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    RNA

    1. XR_005505573.2 RNA Sequence