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    Haus7 HAUS augmin-like complex, subunit 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293844, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Haus7provided by RGD
    Official Full Name
    HAUS augmin-like complex, subunit 7provided by RGD
    Primary source
    RGD:1562991
    See related
    Ensembl:ENSRNOG00000055648 AllianceGenome:RGD:1562991
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Uchl5ip; RGD1562991
    Summary
    Predicted to enable microtubule minus-end binding activity and thioesterase binding activity. Predicted to be involved in centrosome cycle and spindle assembly. Predicted to be located in centrosome and mitotic spindle microtubule. Predicted to be part of HAUS complex. Orthologous to human HAUS7 (HAUS augmin like complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 130.0), Adrenal (RPKM 108.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Haus7 in Genome Data Viewer
    Location:
    Xq37
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156306320..156331940, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151154979..151174441, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (157347222..157372796)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 6, pseudogene 1 Neighboring gene ZFP92 zinc finger protein Neighboring gene three prime repair exonuclease 2 Neighboring gene biglycan Neighboring gene ATPase plasma membrane Ca2+ transporting 3 Neighboring gene cyclin Q, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of two proteins, S14 and UIP1, that interact with UCH37. Li T, et al. FEBS Lett, 2001 Jan 19. PMID 11163772
    2. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Lawo S, et al. Curr Biol, 2009 May 26. PMID 19427217
    3. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Uehara R, et al. Proc Natl Acad Sci U S A, 2009 Apr 28. PMID 19369198, Free PMC Article
    4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thioesterase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of HAUS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of HAUS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    HAUS augmin-like complex subunit 7
    Names
    UCHL5 interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277272.1 → NP_001264201.1  HAUS augmin-like complex subunit 7

      See identical proteins and their annotated locations for NP_001264201.1

      Status: VALIDATED

      Source sequence(s)
      BC158688, JAXUCZ010000021
      UniProtKB/TrEMBL
      B0BN53
      Conserved Domains (1) summary
      pfam06694
      Location:68 → 310
      Plant_NMP1; Plant nuclear matrix protein 1 (NMP1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      156306320..156331940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099522.2 → XP_038955450.1  HAUS augmin-like complex subunit 7 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ1
      Related
      ENSRNOP00000070747.2

    2. XM_063279832.1 → XP_063135902.1  HAUS augmin-like complex subunit 7 isoform X2

      UniProtKB/TrEMBL
      B0BN53

    3. XM_063279833.1 → XP_063135903.1  HAUS augmin-like complex subunit 7 isoform X3

    4. XM_063279834.1 → XP_063135904.1  HAUS augmin-like complex subunit 7 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A6G6

    RNA

    1. XR_010061174.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001110488.1: Suppressed sequence

      Description
      NM_001110488.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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