Arsa arylsulfatase A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arsaprovided by RGD
Official Full Name: arylsulfatase Aprovided by RGD
Primary source: RGD:1310381
See related: Ensembl:ENSRNOG00000012953 AllianceGenome:RGD:1310381
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables arylsulfatase activity. Involved in several processes, including response to estrogen; response to ethanol; and response to methylmercury. Located in cytoplasmic vesicle; extracellular space; and lysosome. Is extrinsic component of external side of plasma membrane. Used to study hypothyroidism. Human ortholog(s) of this gene implicated in metachromatic leukodystrophy. Orthologous to human ARSA (arylsulfatase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 217.6), Kidney (RPKM 146.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (122422971..122426971, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (120542788..120547577, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (130446644..130452632, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

DLAT (e-PCR)
- UniSTS:48474

BI277783 (e-PCR)
- UniSTS:243853

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arylsulfatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arylsulfatase activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables cerebroside-sulfatase activity	IEA Inferred from Electronic Annotation more info
enables sulfuric ester hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in autophagy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to methylmercury	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient	IDA Inferred from Direct Assay more info	PubMed
involved_in response to pH	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extrinsic component of external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arylsulfatase A

NP_001030105.2

EC 3.1.6.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034933.3 → NP_001030105.2 arylsulfatase A precursor

See identical proteins and their annotated locations for NP_001030105.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

F7FF93, Q32KK2, Q3KR80

Related

ENSRNOP00000017782.4, ENSRNOT00000017783.7

Conserved Domains (2) summary

COG3119
Location:17 → 470

AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]

cl23718
Location:20 → 503

ALP_like; alkaline phosphatases and sulfatases