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    Hs1bp3 HCLS1 binding protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313950, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Hs1bp3provided by RGD
    Official Full Name
    HCLS1 binding protein 3provided by RGD
    Primary source
    RGD:1311331
    See related
    Ensembl:ENSRNOG00000006062 AllianceGenome:RGD:1311331
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311331
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and mitochondrion. Human ortholog(s) of this gene implicated in essential tremor 2. Orthologous to human HS1BP3 (HCLS1 binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 71.3), Adrenal (RPKM 49.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hs1bp3 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (36911864..36942126)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (31192568..31222835)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (33517711..33548015)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene lipid droplet associated hydrolase Neighboring gene growth differentiation factor 7 Neighboring gene uncharacterized LOC134479336 Neighboring gene uncharacterized LOC120103507 Neighboring gene uncharacterized LOC102550373 Neighboring gene uncharacterized LOC120103508

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human HS1BP3 induces cell apoptosis and activates AP-1. Shi T, et al. BMB Rep, 2011 Jun. PMID 21699750
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    HCLS1-binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398778.1 → NP_001385707.1  HCLS1-binding protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      Related
      ENSRNOP00000007991.6, ENSRNOT00000007991.8
      Conserved Domains (1) summary
      cd06868
      Location:19 → 138
      PX_HS1BP3; The phosphoinositide binding Phox Homology domain of HS1BP3

    2. NM_001398779.1 → NP_001385708.1  HCLS1-binding protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      Conserved Domains (1) summary
      cd06868
      Location:19 → 138
      PX_HS1BP3; The phosphoinositide binding Phox Homology domain of HS1BP3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      36911864..36942126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113131.2 → XP_038969059.1  HCLS1-binding protein 3 isoform X1

      Conserved Domains (1) summary
      cl02563
      Location:1 → 28
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    Nucleotide Protein Strain
    Heading Accession and Version

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