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    Tafa4 TAFA chemokine like family member 4 [ Mus musculus (house mouse) ]

    Gene ID: 320701, updated on 12-May-2024

    Summary

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    Official Symbol
    Tafa4provided by MGI
    Official Full Name
    TAFA chemokine like family member 4provided by MGI
    Primary source
    MGI:MGI:2444563
    See related
    Ensembl:ENSMUSG00000046500 AllianceGenome:MGI:2444563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tafa-4; Fam19a4; C130034I18Rik; Fam19a4 Tafa-4
    Summary
    Enables receptor ligand activity. Involved in several processes, including macrophage chemotaxis; phagocytosis; and superoxide anion generation. Acts upstream of or within regulation of membrane potential and regulation of sensory perception of pain. Located in extracellular space. Is expressed in central nervous system; dorsal root ganglion; inner ear; and tooth. Orthologous to human TAFA4 (TAFA chemokine like family member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Tafa4 in Genome Data Viewer
    Location:
    6 D3; 6 44.8 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (96808167..97037452, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (96831206..97060411, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 1 Neighboring gene predicted gene, 22971 Neighboring gene STARR-seq mESC enhancer starr_16762 Neighboring gene predicted gene, 26011 Neighboring gene STARR-seq mESC enhancer starr_16763 Neighboring gene STARR-seq mESC enhancer starr_16764 Neighboring gene STARR-seq mESC enhancer starr_16765 Neighboring gene STARR-seq mESC enhancer starr_16766 Neighboring gene STARR-seq mESC enhancer starr_16767 Neighboring gene STARR-seq mESC enhancer starr_16770 Neighboring gene STARR-seq mESC enhancer starr_16771 Neighboring gene STARR-seq mESC enhancer starr_16773 Neighboring gene STARR-seq mESC enhancer starr_16775 Neighboring gene STARR-seq mESC enhancer starr_16776 Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene predicted gene, 26175 Neighboring gene TATA element modulatory factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TAFA4 Reverses Mechanical Allodynia through Activation of GABAergic Transmission and Microglial Process Retraction. Kambrun C, et al. Cell Rep, 2018 Mar 13. PMID 29539418
    2. TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K(+) current. Yoo S, et al. Cell Rep, 2021 Oct 26. PMID 34706225
    3. Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner. Bohic M, et al. Cell Rep, 2020 Jan 21. PMID 31968239
    4. TAFA4, a chemokine-like protein, modulates injury-induced mechanical and chemical pain hypersensitivity in mice. Delfini MC, et al. Cell Rep, 2013 Oct 31. PMID 24139797
    5. Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcεRI in mast cells. Zhou C, et al. Clin Exp Immunol, 2023 Mar 8. PMID 36368013, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcepsilonRI in mast cells.
      Title: Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcεRI in mast cells.
    2. TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K(+) current.
      Title: TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K(+) current.
    3. Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions.
      Title: Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions.
    4. TAFA4 is required to maintain the normal threshold of injury-induced mechanical and chemical pain hypersensitivity and strongly support a potential role of TAFA4 as a potent analgesic in the settings of inflammation and neuropathy.
      Title: TAFA4, a chemokine-like protein, modulates injury-induced mechanical and chemical pain hypersensitivity in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107151

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macrophage chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in superoxide anion generation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chemokine-like protein TAFA-4
    Names
    family with sequence similarity 19 (chemokine (C-C motif)-like), member A4
    family with sequence similarity 19, member A4
    protein FAM19A4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177233.5 → NP_796207.2  chemokine-like protein TAFA-4 precursor

      See identical proteins and their annotated locations for NP_796207.2

      Status: VALIDATED

      Source sequence(s)
      AC133086, AC160399
      Consensus CDS
      CCDS51858.1
      UniProtKB/Swiss-Prot
      Q5FWC0, Q7TPG5, Q8BV02
      Related
      ENSMUSP00000086710.5, ENSMUST00000089295.6
      Conserved Domains (1) summary
      pfam12020
      Location:46 → 133
      TAFA; TAFA family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      96808167..97037452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166237.1 → XP_036022130.1  chemokine-like protein TAFA-4 isoform X2

      UniProtKB/Swiss-Prot
      Q5FWC0, Q7TPG5, Q8BV02
      Conserved Domains (1) summary
      pfam12020
      Location:46 → 133
      TAFA; TAFA family

    2. XM_036166236.1 → XP_036022129.1  chemokine-like protein TAFA-4 isoform X2

      UniProtKB/Swiss-Prot
      Q5FWC0, Q7TPG5, Q8BV02
      Conserved Domains (1) summary
      pfam12020
      Location:46 → 133
      TAFA; TAFA family

    3. XM_017321648.3 → XP_017177137.1  chemokine-like protein TAFA-4 isoform X2

      UniProtKB/Swiss-Prot
      Q5FWC0, Q7TPG5, Q8BV02
      Conserved Domains (1) summary
      pfam12020
      Location:46 → 133
      TAFA; TAFA family

    4. XM_030255465.1 → XP_030111325.1  chemokine-like protein TAFA-4 isoform X1

      Conserved Domains (1) summary
      pfam12020
      Location:77 → 164
      TAFA; TAFA family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TPG5.1 GenPept UniProtKB/Swiss-Prot:Q7TPG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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