Kat6a K(lysine) acetyltransferase 6A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kat6aprovided by MGI
Official Full Name: K(lysine) acetyltransferase 6Aprovided by MGI
Primary source: MGI:MGI:2442415
See related: Ensembl:ENSMUSG00000031540 AllianceGenome:MGI:2442415
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MOZ; Myst3; Zfp220; 1500036M03; 9930021N24Rik
Summary: Enables chromatin binding activity. Acts upstream of or within several processes, including circulatory system development; face morphogenesis; and negative regulation of DNA-binding transcription factor activity. Located in nucleus. Is expressed in several structures, including brain; early embryo; genitourinary system; and liver. Used to study DiGeorge syndrome. Human ortholog(s) of this gene implicated in Arboleda-Tham syndrome and acute myeloid leukemia. Orthologous to human KAT6A (lysine acetyltransferase 6A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 13.7), CNS E11.5 (RPKM 10.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 11.42 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (23349458..23433275)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (22859442..22943259)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lysine acetyltransferase 6A maintains CD4[+] T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity.
Title: Lysine acetyltransferase 6A maintains CD4(+) T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity.
MOZ is critical for the development of MOZ/MLL fusion-induced leukemia through regulation of Hoxa9/Meis1 expression.
Title: MOZ is critical for the development of MOZ/MLL fusion-induced leukemia through regulation of Hoxa9/Meis1 expression.
Identification of a specific program by which the chromatin modifier MOZ regulates craniofacial development.
Title: MOZ directs the distal-less homeobox gene expression program during craniofacial development.
Loss of MOZ in adult mice leads to the rapid loss of hematopoietic stem cells as defined by transplantation.
Title: MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells.
Our work revealed that MOZ and BMI1 regulate HSCs in a synergistic manner by acting on distinct processes required to maintain HSCs.
Title: MOZ and BMI1 act synergistically to maintain hematopoietic stem cells.
BRPF2-MOZ complexes play an important role in the differentiation of embryonic stem cells via H3K14 acetylation.
Title: The BRPF2/BRD1-MOZ complex is involved in retinoic acid-induced differentiation of embryonic stem cells.
the expression of MOZ-TIF2 fusion protein represses the transcription of p16INK4a and p19ARF and blocks senescence.
Title: Expression of the MOZ-TIF2 oncoprotein in mice represses senescence.
Study establishes that MOZ is an upstream inhibitor of the INK4A-ARF pathway, and suggests that inhibiting MOZ may be one way to induce senescence in proliferative tumor cells.
Title: MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway.
these data suggest that the molecular pathogenesis of ventricular septal defectss in Moz germline mutant mice is due to loss of MOZ-dependant activation of mesodermal Tbx1 and Tbx5 expression.
Title: Mesodermal expression of Moz is necessary for cardiac septum development.
MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development
Title: MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Myst3 (e-PCR), detects polymorphism
- UniSTS:516609

Myst3 (e-PCR), detects polymorphism
- UniSTS:516610

Myst3 (e-PCR), detects polymorphism
- UniSTS:516611

Myst3 (e-PCR), detects polymorphism
- UniSTS:516612

32.MMHAP6FRC11.seq (e-PCR)
- UniSTS:123998

Myst3 (e-PCR), detects polymorphism
- UniSTS:532320

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IGI Inferred from Genetic Interaction more info	PubMed
enables histone H3 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K14 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K9 acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H4K12 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K16 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K5 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K8 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within aorta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within face morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within face morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in protein acetylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of developmental process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of hemopoiesis	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MOZ/MORF histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MOZ/MORF histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in PML body	ISO Inferred from Sequence Orthology more info
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone acetyltransferase KAT6A

Names: MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MYST histone acetyltransferase (monocytic leukemia) 3; histone acetyltransferase MYST3; monocytic leukemia zinc finger homolog; monocytic leukemia zinc finger protein; zinc finger protein 220

NP_001074618.1

EC 2.3.1.48

NP_001351378.1

EC 2.3.1.48

XP_006509176.1

EC 2.3.1.48

XP_017168283.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081149.2 → NP_001074618.1 histone acetyltransferase KAT6A

See identical proteins and their annotated locations for NP_001074618.1

Status: VALIDATED

Source sequence(s)

AC115361, AC142414

Consensus CDS

CCDS40294.1

UniProtKB/Swiss-Prot

Q8BW52, Q8BYH1, Q8BZ21, Q8C1F3

UniProtKB/TrEMBL

G3X940

Related

ENSMUSP00000038181.7, ENSMUST00000044331.7

Conserved Domains (4) summary

smart00526
Location:85 → 162

H15; Domain in histone families 1 and 5

cd15527
Location:264 → 310

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15618
Location:205 → 262

PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cl27485
Location:503 → 777

MOZ_SAS; MOZ/SAS family
NM_001364449.1 → NP_001351378.1 histone acetyltransferase KAT6A

Status: VALIDATED

Source sequence(s)

AC115361, AK132474

Consensus CDS

CCDS40294.1

UniProtKB/Swiss-Prot

Q8BW52, Q8BYH1, Q8BZ21, Q8C1F3

UniProtKB/TrEMBL

G3X940

Related

ENSMUSP00000106324.2, ENSMUST00000110696.8

Conserved Domains (4) summary

smart00526
Location:85 → 162

H15; Domain in histone families 1 and 5

cd15527
Location:264 → 310

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15618
Location:205 → 262

PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cl27485
Location:503 → 777

MOZ_SAS; MOZ/SAS family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

23349458..23433275

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509113.2 → XP_006509176.1 histone acetyltransferase KAT6A isoform X1

UniProtKB/Swiss-Prot

Q8BW52, Q8BYH1, Q8BZ21, Q8C1F3

Conserved Domains (4) summary

smart00526
Location:85 → 162

H15; Domain in histone families 1 and 5

PLN00104
Location:496 → 770

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:264 → 310

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15618
Location:205 → 262

PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
XM_017312794.2 → XP_017168283.1 histone acetyltransferase KAT6A isoform X2

Conserved Domains (1) summary

PLN00104
Location:68 → 342

PLN00104; MYST -like histone acetyltransferase; Provisional