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    Garre1 granule associated Rac and RHOG effector 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308509, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Garre1provided by RGD
    Official Full Name
    granule associated Rac and RHOG effector 1provided by RGD
    Primary source
    RGD:1308428
    See related
    Ensembl:ENSRNOG00000021129 AllianceGenome:RGD:1308428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308428
    Summary
    Predicted to enable CCR4-NOT complex binding activity and small GTPase binding activity. Predicted to be involved in Rac protein signal transduction. Predicted to be located in P-body. Orthologous to human GARRE1 (granule associated Rac and RHOG effector 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 149.4), Heart (RPKM 134.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Garre1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95999305..96077641, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86862121..86939725, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (90097331..90176119, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene programmed cell death 2-like Neighboring gene glucose-6-phosphate isomerase Neighboring gene ribosomal protein S23, pseudogene 12 Neighboring gene uncharacterized LOC120099790 Neighboring gene uncharacterized LOC120099791 Neighboring gene LSM14A mRNA processing body assembly factor Neighboring gene transfer RNA serine (anticodon AGA) 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Youn JY, et al. Mol Cell, 2018 Feb 1. PMID 29395067
    2. Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Bagci H, et al. Nat Cell Biol, 2020 Jan. PMID 31871319
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CCR4-NOT complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CCR4-NOT complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    granule associated Rac and RHOG effector protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271233.1 → NP_001258162.1  granule associated Rac and RHOG effector protein 1

      See identical proteins and their annotated locations for NP_001258162.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8J8XFB5, A6JA91
      Related
      ENSRNOP00000067998.1, ENSRNOT00000076987.3
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      95999305..96077641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261654.1 → XP_063117724.1  granule associated Rac and RHOG effector protein 1 isoform X2

    2. XM_008759155.4 → XP_008757377.1  granule associated Rac and RHOG effector protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008757377.1

      UniProtKB/TrEMBL
      A0A8J8XFB5, A6JA91
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    3. XM_006228850.5 → XP_006228912.1  granule associated Rac and RHOG effector protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006228912.1

      UniProtKB/TrEMBL
      A0A8J8XFB5, A6JA91
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    4. XM_008759157.4 → XP_008757379.1  granule associated Rac and RHOG effector protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008757379.1

      UniProtKB/TrEMBL
      A0A8J8XFB5, A6JA91
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    5. XM_006228851.5 → XP_006228913.1  granule associated Rac and RHOG effector protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006228913.1

      UniProtKB/TrEMBL
      A0A8J8XFB5, A6JA91
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    6. XM_063261655.1 → XP_063117725.1  granule associated Rac and RHOG effector protein 1 isoform X3

    7. XM_063261650.1 → XP_063117720.1  granule associated Rac and RHOG effector protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8J8XFB5

    8. XM_063261647.1 → XP_063117717.1  granule associated Rac and RHOG effector protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8J8XFB5

    9. XM_039111613.2 → XP_038967541.1  granule associated Rac and RHOG effector protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8J8XFB5, A6JA91
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    10. XM_008759156.4 → XP_008757378.1  granule associated Rac and RHOG effector protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008757378.1

      UniProtKB/TrEMBL
      A0A8J8XFB5, A6JA91
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    11. XM_063261657.1 → XP_063117727.1  granule associated Rac and RHOG effector protein 1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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