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    Mapre3 microtubule-associated protein, RP/EB family, member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298848, updated on 2-May-2024

    Summary

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    Official Symbol
    Mapre3provided by RGD
    Official Full Name
    microtubule-associated protein, RP/EB family, member 3provided by RGD
    Primary source
    RGD:1359297
    See related
    Ensembl:ENSRNOG00000008961 AllianceGenome:RGD:1359297
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including identical protein binding activity; microtubule plus-end binding activity; and protein C-terminus binding activity. Predicted to be involved in several processes, including positive regulation of nitrogen compound metabolic process; protein localization to microtubule plus-end; and regulation of microtubule polymerization. Predicted to act upstream of or within positive regulation of microtubule plus-end binding activity. Predicted to be located in midbody; mitotic spindle astral microtubule end; and perinuclear region of cytoplasm. Predicted to be active in microtubule cytoskeleton. Predicted to colocalize with microtubule. Orthologous to human MAPRE3 (microtubule associated protein RP/EB family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 149.1), Brain (RPKM 111.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mapre3 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (31233736..31278626, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (25513800..25558876, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26878738..26923459, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479111 Neighboring gene transmembrane protein 214 Neighboring gene uncharacterized LOC108351190 Neighboring gene uncharacterized LOC108351187 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene dihydropyrimidinase-like 5 Neighboring gene uncharacterized LOC120103488

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PSD-95 alters microtubule dynamics via an association with EB3. Sweet ES, et al. J Neurosci, 2011 Jan 19. PMID 21248129, Free PMC Article
    2. The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons. Poobalasingam T, et al. J Neurochem, 2022 Jan. PMID 34478582
    3. Microtubules that form the stationary lattice of muscle fibers are dynamic and nucleated at Golgi elements. Oddoux S, et al. J Cell Biol, 2013 Oct 28. PMID 24145165, Free PMC Article
    4. End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segment. Leterrier C, et al. Proc Natl Acad Sci U S A, 2011 May 24. PMID 21551097, Free PMC Article
    5. EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue. Nakagawa H, et al. Oncogene, 2000 Jan 13. PMID 10644998

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons.
      Title: The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons.
    2. EB3 and EB1 coordinate a molecular and functional interplay between ankyrin G (ankG)and the axon initial segment microtubules that supports the central role of ankG in the maintenance of neuronal polarity
      Title: End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segment.
    3. The interaction between PSD-95 and EB3 in determining dendritic morphology by regulation of microtubules elucidates a function for a novel region of EB3.
      Title: PSD-95 alters microtubule dynamics via an association with EB3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC94312

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle astral microtubule end ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated protein RP/EB family member 3
    Names
    EB1 protein family member 3
    EB3
    EBF3
    RP3
    end-binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007656.1 → NP_001007657.1  microtubule-associated protein RP/EB family member 3

      See identical proteins and their annotated locations for NP_001007657.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083589
      UniProtKB/Swiss-Prot
      Q5XIT1
      Related
      ENSRNOP00000011877.2, ENSRNOT00000011874.5
      Conserved Domains (1) summary
      COG5217
      Location:16 → 279
      BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      31233736..31278626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764513.4 → XP_008762735.1  microtubule-associated protein RP/EB family member 3 isoform X2

      See identical proteins and their annotated locations for XP_008762735.1

      UniProtKB/TrEMBL
      A0A8I6A6V2
      Related
      ENSRNOP00000088597.1
      Conserved Domains (1) summary
      COG5217
      Location:16 → 264
      BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

    2. XM_008764512.4 → XP_008762734.1  microtubule-associated protein RP/EB family member 3 isoform X1

      See identical proteins and their annotated locations for XP_008762734.1

      UniProtKB/Swiss-Prot
      Q5XIT1
      Conserved Domains (1) summary
      COG5217
      Location:16 → 279
      BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

    3. XM_039111914.2 → XP_038967842.1  microtubule-associated protein RP/EB family member 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XIT1
      Conserved Domains (1) summary
      COG5217
      Location:16 → 279
      BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

    RNA

    1. XR_010052059.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIT1.1 GenPept UniProtKB/Swiss-Prot:Q5XIT1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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