Tnik TRAF2 and NCK interacting kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnikprovided by RGD
Official Full Name: TRAF2 and NCK interacting kinaseprovided by RGD
Primary source: RGD:1561817
See related: Ensembl:ENSRNOG00000012422 AllianceGenome:RGD:1561817
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561817
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of dendrite morphogenesis. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynapse. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TNIK (TRAF2 and NCK interacting kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 138.2), Lung (RPKM 92.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q24

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (113112937..113511341)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (111184352..111587993)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (113984599..114391805)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TNIK maintains levels of glutamate receptors and other key postsynaptic density (PSD) proteins at the synapse, with loss of TNIK protein or inhibition of TNIK activity causing rapid degradation of PSD constituents.
Title: The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.
Expression of MINK and TNIK in neurons is required for normal dendritic arborization and surface expression of AMPA receptors.
Title: MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF386414 (e-PCR)
- UniSTS:243724

AU027546 (e-PCR)
- UniSTS:113200

D2Rat280 (e-PCR), detects polymorphism
- UniSTS:227419

RH142274 (e-PCR)
- UniSTS:231521

BF405470 (e-PCR)
- UniSTS:247917

D2Ulb10 (e-PCR)
- UniSTS:519031

AI451411 (e-PCR)
- UniSTS:165243

D2Got187 (e-PCR)
- UniSTS:115871

D2Rat77 (e-PCR), detects polymorphism
- UniSTS:118723

AW532604 (e-PCR)
- UniSTS:260568

BQ207408 (e-PCR)
- UniSTS:261611

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in microvillus assembly	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TRAF2 and NCK-interacting protein kinase

NP_001099892.1

EC 2.7.11.1

XP_008759119.2

EC 2.7.11.1

XP_017446219.1

EC 2.7.11.1

XP_017446220.1

EC 2.7.11.1

XP_017446221.1

EC 2.7.11.1

XP_063137616.1

EC 2.7.11.1

XP_063137617.1

EC 2.7.11.1

XP_063137618.1

EC 2.7.11.1

XP_063137619.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106422.1 → NP_001099892.1 TRAF2 and NCK-interacting protein kinase

See identical proteins and their annotated locations for NP_001099892.1

Status: PROVISIONAL

Source sequence(s)

CH473961

UniProtKB/TrEMBL

A0A8I5ZV95, A6IHI7

Related

ENSRNOP00000016799.4, ENSRNOT00000016799.5

Conserved Domains (3) summary

smart00036
Location:1034 → 1326

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:25 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06637
Location:18 → 313

STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

113112937..113511341

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281546.1 → XP_063137616.1 TRAF2 and NCK-interacting protein kinase isoform X1
XM_017590730.3 → XP_017446219.1 TRAF2 and NCK-interacting protein kinase isoform X2

UniProtKB/TrEMBL

A0A0G2K490, A0A8I5ZV95

Related

ENSRNOP00000072950.1
XM_017590731.3 → XP_017446220.1 TRAF2 and NCK-interacting protein kinase isoform X3

UniProtKB/TrEMBL

A0A8I5ZV95, A0A8I6GLD8, A6IHI6

Related

ENSRNOP00000095929.1

Conserved Domains (3) summary

smart00036
Location:1034 → 1332

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:25 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06637
Location:18 → 313

STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
XM_063281547.1 → XP_063137617.1 TRAF2 and NCK-interacting protein kinase isoform X4
XM_017590732.3 → XP_017446221.1 TRAF2 and NCK-interacting protein kinase isoform X5

UniProtKB/TrEMBL

A0A8I6GFX7
XM_063281548.1 → XP_063137618.1 TRAF2 and NCK-interacting protein kinase isoform X6
XM_008760897.4 → XP_008759119.2 TRAF2 and NCK-interacting protein kinase isoform X7

UniProtKB/TrEMBL

A0A8I6GFX7
XM_063281549.1 → XP_063137619.1 TRAF2 and NCK-interacting protein kinase isoform X8