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    Qpctl glutaminyl-peptide cyclotransferase-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292687, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Qpctlprovided by RGD
    Official Full Name
    glutaminyl-peptide cyclotransferase-likeprovided by RGD
    Primary source
    RGD:1308128
    See related
    Ensembl:ENSRNOG00000015413 AllianceGenome:RGD:1308128
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308128
    Summary
    Predicted to enable glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Predicted to be involved in peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase. Predicted to be located in Golgi apparatus. Orthologous to human QPCTL (glutaminyl-peptide cyclotransferase like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 46.3), Adrenal (RPKM 45.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Qpctl in Genome Data Viewer
    Location:
    1q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (87916771..87925843, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (78786730..78797956, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80046975..80057022, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene meiosis initiator Neighboring gene SIX homeobox 5 Neighboring gene F-box protein 46 Neighboring gene small nuclear ribonucleoprotein D2 polypeptide Neighboring gene gastric inhibitory polypeptide receptor Neighboring gene EMAP like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. Huang KF, et al. J Biol Chem, 2011 Apr 8. PMID 21288892, Free PMC Article
    2. Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery. Cynis H, et al. J Mol Biol, 2008 Jun 20. PMID 18486145
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutaminyl-peptide cyclotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminyl-peptide cyclotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutaminyl-peptide cyclotransferase-like protein
    NP_001099700.1
    XP_006228464.1
    XP_038959895.1
    XP_038959901.1
    XP_063139247.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106230.1 → NP_001099700.1  glutaminyl-peptide cyclotransferase-like protein

      See identical proteins and their annotated locations for NP_001099700.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473979
      UniProtKB/TrEMBL
      B5DFI7, F7FB82
      Related
      ENSRNOP00000021200.4, ENSRNOT00000021200.6
      Conserved Domains (1) summary
      cd03880
      Location:80 → 380
      M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      87916771..87925843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103973.2 → XP_038959901.1  glutaminyl-peptide cyclotransferase-like protein isoform X3

      UniProtKB/TrEMBL
      A6J8K1
      Conserved Domains (1) summary
      cl14876
      Location:82 → 263
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    2. XM_006228402.5 → XP_006228464.1  glutaminyl-peptide cyclotransferase-like protein isoform X1

      Conserved Domains (1) summary
      cd03880
      Location:80 → 341
      M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

    3. XM_039103967.2 → XP_038959895.1  glutaminyl-peptide cyclotransferase-like protein isoform X2

      UniProtKB/TrEMBL
      A6J8K1
      Conserved Domains (1) summary
      cl14876
      Location:82 → 296
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    4. XM_063283177.1 → XP_063139247.1  glutaminyl-peptide cyclotransferase-like protein isoform X4

    RNA

    1. XR_005501477.2 RNA Sequence

    2. XR_005501480.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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