Sympk symplekin scaffold protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sympkprovided by RGD
Official Full Name: symplekin scaffold proteinprovided by RGD
Primary source: RGD:1306735
See related: Ensembl:ENSRNOG00000014353 AllianceGenome:RGD:1306735
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hfn3g
Summary: Predicted to be involved in mRNA polyadenylation; negative regulation of protein binding activity; and positive regulation of protein dephosphorylation. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human SYMPK (symplekin scaffold protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 108.2), Testes (RPKM 92.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (87800416..87828727)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (78672372..78700684)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (79931097..79959461)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW529469 (e-PCR)
- UniSTS:247346

BF390442 (e-PCR)
- UniSTS:249468

RH126861 (e-PCR)
- UniSTS:208085

Sympk (e-PCR), detects polymorphism
- UniSTS:525277

NoName (e-PCR)
- UniSTS:237793

AI449890 (e-PCR)
- UniSTS:164351

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of mRNA cleavage and polyadenylation specificity factor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear stress granule	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: symplekin

Names: hepatocyte nuclear factor 3 gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.