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    Izumo3 IZUMO family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 69314, updated on 12-May-2024

    Summary

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    Official Symbol
    Izumo3provided by MGI
    Official Full Name
    IZUMO family member 3provided by MGI
    Primary source
    MGI:MGI:1916564
    See related
    Ensembl:ENSMUSG00000028533 AllianceGenome:MGI:1916564
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700011H22Rik
    Summary
    Enables protein homodimerization activity. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Orthologous to human IZUMO3 (IZUMO family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 9.1) See more
    Orthologs
    human all
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    Genomic context

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    See Izumo3 in Genome Data Viewer
    Location:
    4 C5; 4 43.16 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (92032555..92035462, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (92144318..92147225, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene glutaredoxin 3 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 40203 Neighboring gene La ribonucleoprotein 7, transcriptional regulator, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IZUMO family member 3, IZUMO3, is involved in male fertility through the acrosome formation. Inoue N, et al. Mol Reprod Dev, 2021 Jul. PMID 34114279
    2. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. Ellerman DA, et al. Mol Reprod Dev, 2009 Dec. PMID 19658160, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IZUMO family member 3, IZUMO3, is involved in male fertility through the acrosome formation.
      Title: IZUMO family member 3, IZUMO3, is involved in male fertility through the acrosome formation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    izumo sperm-egg fusion protein 3
    Names
    transmembrane protein C9orf134

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027034.1 → NP_081310.1  izumo sperm-egg fusion protein 3 precursor

      See identical proteins and their annotated locations for NP_081310.1

      Status: VALIDATED

      Source sequence(s)
      AL807382
      Consensus CDS
      CCDS51231.1
      UniProtKB/Swiss-Prot
      A6PWV3, Q9DAG1
      Related
      ENSMUSP00000102725.2, ENSMUST00000107108.8
      Conserved Domains (1) summary
      pfam15005
      Location:23 → 164
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      92032555..92035462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320383.2 → XP_017175872.1  izumo sperm-egg fusion protein 3 isoform X1

      Conserved Domains (1) summary
      pfam15005
      Location:23 → 164
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    RNA

    1. XR_003955008.1 RNA Sequence

    2. XR_003955009.1 RNA Sequence

    3. XR_004941954.1 RNA Sequence

    4. XR_003955010.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6PWV3.1 GenPept UniProtKB/Swiss-Prot:A6PWV3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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