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    Alkbh6 alkB homolog 6 [ Mus musculus (house mouse) ]

    Gene ID: 233065, updated on 4-May-2024

    Summary

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    Official Symbol
    Alkbh6provided by MGI
    Official Full Name
    alkB homolog 6provided by MGI
    Primary source
    MGI:MGI:2142037
    See related
    Ensembl:ENSMUSG00000042831 AllianceGenome:MGI:2142037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Abh6; C130099A02
    Summary
    Predicted to enable dioxygenase activity and metal ion binding activity. Predicted to be located in focal adhesion and nucleoplasm. Orthologous to human ALKBH6 (alkB homolog 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 102.7), ovary adult (RPKM 80.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Alkbh6 in Genome Data Viewer
    Location:
    7 B1; 7 17.38 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30008178..30013728)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30308753..30314303)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700020L13 gene Neighboring gene THAP domain containing 8, pseudogene Neighboring gene CAP-GLY domain containing linker protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E3711 Neighboring gene spectrin repeat containing, nuclear envelope family member 4 Neighboring gene STARR-positive B cell enhancer ABC_E1730 Neighboring gene succinate dehydrogenase complex assembly factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Repair of methylation damage in DNA and RNA by mammalian AlkB homologues. Lee DH, et al. J Biol Chem, 2005 Nov 25. PMID 16174769
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables 2-oxoglutarate-dependent dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alpha-ketoglutarate-dependent dioxygenase alkB homolog 6
    Names
    alkB, alkylation repair homolog 6
    alkylated DNA repair protein alkB homolog 6
    probable alpha-ketoglutarate-dependent dioxygenase ABH6
    NP_932144.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198027.3 → NP_932144.2  alpha-ketoglutarate-dependent dioxygenase alkB homolog 6

      See identical proteins and their annotated locations for NP_932144.2

      Status: VALIDATED

      Source sequence(s)
      AC149067
      Consensus CDS
      CCDS21085.1
      UniProtKB/Swiss-Prot
      G3X994, Q8K2U2
      UniProtKB/TrEMBL
      D3Z1T0
      Related
      ENSMUSP00000051515.6, ENSMUST00000060834.12
      Conserved Domains (1) summary
      cl21496
      Location:24 → 224
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30008178..30013728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2U2.3 GenPept UniProtKB/Swiss-Prot:Q8K2U2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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